caa a22 4500 465805140 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF03349585 doi (NATIONALLICENCE)springer-10.1007/BF03349585 Prolactin response to thyrotropin-releasing hormone in normoprolactinemic patients with ovulatory dysfunction and its use for selection of candidates for bromocriptine therapy [Elektronische Daten] [E. Steinberger, S. Nader, L. Rodriguez-Rigau, C. Ayala, K. Smith] It has been suggested in the past that some normoprolactinemic patients with amenorrhea or infertility respond to treatment with bromocriptine. However, the beneficial effect of this therapy in normoprolactinemic women remains controversial. Some authors have suggested that the responders suffer with "reactive” hyperprolactinemia and that this may be detected with thyrotropin releasing hormone (TRH) stimulation. In this study, we performed TRH stimulation tests in 538 patients with ovulatory dysfunction. Only those patients showing a peak prolactin response after TRH which exceeded 40 ng/ml were treated with bromocriptine. A direct correlation between peak prolactin level after TRH and a favorable response to treatment was observed. Serum testosterone and DHEA-sulfate levels did not correlate with prolactin response to TRH. A majority of patients with prolactin hyperresponse to TRH did not show a hyperresponse of TSH to TRH. This study suggests that incidence of beneficial response to bromocriptine therapy in normoprolactinemic women with ovulatory dysfunction is significantly higher in subjects exhibiting excessive prolactin response to TRH stimulation. Italian Society of Endocrinology (SIE), 1990 TRH stimulation test nationallicence ovulatory dysfunction nationallicence prolactin nationallicence infertility nationallicence Steinberger E. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut Nader S. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut Rodriguez-Rigau L. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut Ayala C. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut Smith K. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 637-642 0391-4097 13:8<637 1990 13 40618 https://doi.org/10.1007/BF03349585 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349585 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steinberger E. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut NATIONALLICENCE 700 1- Nader S. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut NATIONALLICENCE 700 1- Rodriguez-Rigau L. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut NATIONALLICENCE 700 1- Ayala C. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut NATIONALLICENCE 700 1- Smith K. Texas Foundation for Research in Reproductive Medicine, 7800 Fannin, Suite 502, Houston, Texas, USA aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 637-642 0391-4097 13:8<637 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer