caa a22 4500 465805159 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF03349595 doi (NATIONALLICENCE)springer-10.1007/BF03349595 Pituitary granuloma and pyoderma gangrenosum [Elektronische Daten] [Philippe Chanson, J. Timsit, M. Kujas, A. Violante, P. Guillausseau, P. Derome, A. Warnet, J. Lubetzki] Pyoderma gangrenosum is a rare chronic and recurrent skin disease characterized by progressing lesions from papulopustules to large necrotic sterile ulcers. Its definite etiology remains unknown. In a 40-year-old woman with typical pyoderma gangrenosum an intrasellar mass with suprasellar extension was diagnosed and removed by transsphenoidal surgery. Histo-pathological features of the lesion were those of a nonspecific granulomatous hypophysitis. Five months postoperatively the patient experienced visual defects and hypopituitarism demonstrated by endocrine evaluation. Computerized tomography showed the recurrence of the intrasellar expanding mass. Extensive and repeated evaluation failed to find any evidence of sarcoidosis, tuberculosis or histiocytosis. Corticosteroid therapy was preferred to surgery and 80 mg daily prednisone produced a dramatic shrinkage of the pituitary pseudotumor. Long-term follow-up studies did not disclose any recurrence of the pituitary granulomatous process nor objective evidence of underlying disease even after steroid dosage has been tapered. The hypothesis of a pituitary localization of pyoderma gangrenosum is suggested by the similarity between the histopathologic findings of the two conditions and the excellent response to steroid therapy. Italian Society of Endocrinology (SIE), 1990 Pituitary granuloma nationallicence pyoderma gangrenosum nationallicence corticosteroid therapy nationallicence Chanson Philippe Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut Timsit J. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut Kujas M. Department of Pathology, Faculté de Médecine Pitié-Salpétrière, Paris, France aut Violante A. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut Guillausseau P. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut Derome P. Department of Neurosurgery, Hôpital Foch, Suresnes, France aut Warnet A. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut Lubetzki J. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 677-681 0391-4097 13:8<677 1990 13 40618 https://doi.org/10.1007/BF03349595 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349595 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chanson Philippe Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut NATIONALLICENCE 700 1- Timsit J. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut NATIONALLICENCE 700 1- Kujas M. Department of Pathology, Faculté de Médecine Pitié-Salpétrière, Paris, France aut NATIONALLICENCE 700 1- Violante A. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut NATIONALLICENCE 700 1- Guillausseau P. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut NATIONALLICENCE 700 1- Derome P. Department of Neurosurgery, Hôpital Foch, Suresnes, France aut NATIONALLICENCE 700 1- Warnet A. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut NATIONALLICENCE 700 1- Lubetzki J. Department of Endocrinology, Hôpital Lariboisière, 2, rue A. Paré, F - 75475, Paris Cedex 10, France aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 677-681 0391-4097 13:8<677 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer