caa a22 4500 465805167 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF03349584 doi (NATIONALLICENCE)springer-10.1007/BF03349584 Prolactin response to growth hormone-releasing hormone during chronic thyrotropin-releasing hormone infusion in the treatment of amyotrophic lateral sclerosis [Elektronische Daten] [Pier Chiodini, R. Attanasio, A. Liuzzi, R. Cozzi, P. Orlandi, C. De Palo, D. Dallabonzana, F. Girotti, D. Testa] In six patients suffering from amyotrophic lateral sclerosis we evaluated changes of T4, T3, TSH, PRL, and GH during treatment by continuous iv infusion of TRH for at least 15 days. No clinical improvement was detected. A significant rise of thyroid hormone levels was observed, as well as an upward trend of basal TSH levels and no change of basal PRL and GH levels. TRH acute test-induced TSH and PRL responses became blunted. Treatment provoked also the onset of a responsiveness of PRL to GHRH. The reduced TSH and PRL responses to acute TRH test during treatment could be explained by a down-regulation of TRH pituitary receptors. On the contrary, the onset of PRL responsiveness to GHRH is at present without a satisfactory explanation. Italian Society of Endocrinology (SIE), 1990 TRH nationallicence amyotrophic lateral sclerosis nationallicence TSH nationallicence PRL nationallicence GH nationallicence thyroid hormones nationallicence Chiodini Pier Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut Attanasio R. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut Liuzzi A. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut Cozzi R. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut Orlandi P. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut De Palo C. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut Dallabonzana D. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut Girotti F. Divisione di Neurologia, Istituto Neurologico Besta, Via Celoria 11, 20133, Milano, Italy aut Testa D. Divisione di Neurologia, Istituto Neurologico Besta, Via Celoria 11, 20133, Milano, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 631-636 0391-4097 13:8<631 1990 13 40618 https://doi.org/10.1007/BF03349584 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349584 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chiodini Pier Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut NATIONALLICENCE 700 1- Attanasio R. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut NATIONALLICENCE 700 1- Liuzzi A. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut NATIONALLICENCE 700 1- Cozzi R. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut NATIONALLICENCE 700 1- Orlandi P. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut NATIONALLICENCE 700 1- De Palo C. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut NATIONALLICENCE 700 1- Dallabonzana D. Divisione di Endocrinologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, 20162, Milano, Italy aut NATIONALLICENCE 700 1- Girotti F. Divisione di Neurologia, Istituto Neurologico Besta, Via Celoria 11, 20133, Milano, Italy aut NATIONALLICENCE 700 1- Testa D. Divisione di Neurologia, Istituto Neurologico Besta, Via Celoria 11, 20133, Milano, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 631-636 0391-4097 13:8<631 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer