caa a22 4500 465805221 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF03349583 doi (NATIONALLICENCE)springer-10.1007/BF03349583 Calcitonin and estrogens [Elektronische Daten] [Donato Agnusdei, R. Civitelli, A. Camporeale, C. Gennari] Estrogen deficiency is thought to be the main factor leading to postmenopausal osteoporosis (PMO). A role for calcitonin (CT) has been proposed as mediator of estrogen action on bone, and therefore, as pathogenetic factor of PMO. However, this hypothesis is still controversial. To further analyze the relationships between estrogens and CT in PMO, we studied the effects of one-year estro/progesterone therapy on CT secretory reserve, evaluated by a calcium infusion test in 12 postmenopausal women, as compared to 12 placebo treated subjects. In the hormone treated group, blood levels of CT showed a progressive increase during the study and a plateau was reached at 9 months, indicating that CT production achieved a new steady state. Hormonal therapy also significantly improved the CT response to calcium stimulation test. A concomitant increase of vertebral bone mass was observed in the hormone treated women, who also maintained initial bone density of femoral dyaphyses. On the contrary, the placebo treated group continued to lose bone mineral at both sites. Our study demonstrates that estrogens regulate CT secretion in postmenopausal women; thus, CT may be considered a mediator of estrogen action on bone. Italian Society of Endocrinology (SIE), 1990 Osteoporosis nationallicence calcitonin nationallicence estrogens nationallicence Agnusdei Donato Istituto di Semeiotica Medica, Università di Siena, Piazza Duomo 2, I-53100, Siena, Italy aut Civitelli R. Division of Endocrinology and Bone Metabolism, The Jewish Hospital of St. Louis at Washington University Medical Center, St. Louis, Missouri, USA aut Camporeale A. Istituto di Semeiotica Medica, Università di Siena, Piazza Duomo 2, I-53100, Siena, Italy aut Gennari C. Istituto di Semeiotica Medica, Università di Siena, Piazza Duomo 2, I-53100, Siena, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 625-630 0391-4097 13:8<625 1990 13 40618 https://doi.org/10.1007/BF03349583 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349583 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Agnusdei Donato Istituto di Semeiotica Medica, Università di Siena, Piazza Duomo 2, I-53100, Siena, Italy aut NATIONALLICENCE 700 1- Civitelli R. Division of Endocrinology and Bone Metabolism, The Jewish Hospital of St. Louis at Washington University Medical Center, St. Louis, Missouri, USA aut NATIONALLICENCE 700 1- Camporeale A. Istituto di Semeiotica Medica, Università di Siena, Piazza Duomo 2, I-53100, Siena, Italy aut NATIONALLICENCE 700 1- Gennari C. Istituto di Semeiotica Medica, Università di Siena, Piazza Duomo 2, I-53100, Siena, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 625-630 0391-4097 13:8<625 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer