caa a22 4500 465805280 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF03349588 doi (NATIONALLICENCE)springer-10.1007/BF03349588 Interaction of glucose and pyridostigmine on the secretion of growth hormone (GH) induced by GH-releasing hormone (GHRH) [Elektronische Daten] [G. Delitala, P. Tomasi, M. Palermo, P. Fresu] In order to investigate the mechanisms by which hyperglycaemia induces an inhibition of GHRH-induced GH release, we gave the following treatments to seven normal men: a) GHRH 100 μg iv; b) pyridostigmine (PD) 120 mg po 60 min before GHRH; c) glucose 250 mg/kg iv as a bolus (10 min before GHRH) plus 10 mg/kg/min until the end of the test; d) glucose, pyridostigmine and GHRH as above. Glucose significantly reduced GHRH-stimulated GH levels, whereas PD significantly enhanced them. When PD and glucose were given together, the effect on GHRH-stimulated GH secretion was not different from the algebraic sum of the single effects of the two substances. Thus glucose seems to be able to exert its inhibition, at least partially, also when pyridostigmine is coadministered. Italian Society of Endocrinology (SIE), 1990 GH nationallicence GHRH nationallicence glucose nationallicence pyridostigmine nationallicence acetylcholine nationallicence human nationallicence hyperglycaemia nationallicence Delitala G. Istituto di Ematologia e di Endocrinologia, Cattedra di Endocrinologia, Università di Sassari, Viale S. Pietro 12, 07100, Sassari, Italy aut Tomasi P. Istituto di Ematologia e di Endocrinologia, Cattedra di Endocrinologia, Università di Sassari, Viale S. Pietro 12, 07100, Sassari, Italy aut Palermo M. Istituto di Ematologia e di Endocrinologia, Cattedra di Endocrinologia, Università di Sassari, Viale S. Pietro 12, 07100, Sassari, Italy aut Fresu P. Istituto di Ematologia e di Endocrinologia, Cattedra di Endocrinologia, Università di Sassari, Viale S. Pietro 12, 07100, Sassari, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 653-656 0391-4097 13:8<653 1990 13 40618 https://doi.org/10.1007/BF03349588 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349588 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Delitala G. Istituto di Ematologia e di Endocrinologia, Cattedra di Endocrinologia, Università di Sassari, Viale S. Pietro 12, 07100, Sassari, Italy aut NATIONALLICENCE 700 1- Tomasi P. Istituto di Ematologia e di Endocrinologia, Cattedra di Endocrinologia, Università di Sassari, Viale S. Pietro 12, 07100, Sassari, Italy aut NATIONALLICENCE 700 1- Palermo M. Istituto di Ematologia e di Endocrinologia, Cattedra di Endocrinologia, Università di Sassari, Viale S. Pietro 12, 07100, Sassari, Italy aut NATIONALLICENCE 700 1- Fresu P. Istituto di Ematologia e di Endocrinologia, Cattedra di Endocrinologia, Università di Sassari, Viale S. Pietro 12, 07100, Sassari, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/8(1990-09-01), 653-656 0391-4097 13:8<653 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer