caa a22 4500 465805337 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF03350691 doi (NATIONALLICENCE)springer-10.1007/BF03350691 Ketoconazole reduces elevated serum levels of 1,25-dihydroxy vitamin D in hypercalcemic sarcoidosis [Elektronische Daten] [A. Glass, J. Cerletty, W. Elliott, J. Lemann Jr., R. Gray, C. Eil] The antifungal drug ketoconazole, a cytochrome P450 inhibitor, has been shown to inhibit renal 1,25-dihydroxyvitamin D production in vitro and to lower serum 1,25-dihydroxyvitamin D levels in normal subjects and in patients with primary hyperparathyroidism. To assess the usefulness of this drug in the hypercalcemia of sarcoidosis, a condition thought to result from over-production of 1,25-dihydroxyvitamin D by sarcoid-involved tissues, two men with sarcoidosis, hypercalcemia, and elevated serum levels of 1,25-dihydroxy-vitamin D were given ketoconazole, 600-800 mg per day, for four to six days. Serum 1,25-dihydroxyvitamin D levels were markedly reduced (by approximately 40%) in both patients during ketoconazole administration, but serum calcium was not affected. In both patients, renal function deteriorated during ketoconazole treatment. We conclude that ketoconazole administration can lower the elevated serum 1,25-dihydroxyvitamin D levels in sarcoidosis. However, deterioration of renal function during ketoconazole administration as well as failure of hypercalcemia to be affected during short-term ketoconazole treatment suggest that this drug might not be appropriate for acute treatment of hypercalcemic sarcoidosis. Italian Society of Endocrinology (SIE), 1990 Ketoconazole nationallicence sarcoidosis nationallicence 1,25-dihydroxyvitamin D nationallicence hypercalcemia nationallicence Glass A. Departments of Medicine and Clinical Investigation, Walter Reed Army Medical Center, Endocrinology Service 7D, 20307, Washington, DC, USA aut Cerletty J. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA aut Elliott W. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA aut Lemann Jr. J. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA aut Gray R. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA aut Eil C. Department of Medicine, Roger Williams Hospital, Brown University School of Medicine, 02908, Providence, RI, USA aut Journal of Endocrinological Investigation Springer International Publishing 13/5(1990-05-01), 407-413 0391-4097 13:5<407 1990 13 40618 https://doi.org/10.1007/BF03350691 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03350691 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Glass A. Departments of Medicine and Clinical Investigation, Walter Reed Army Medical Center, Endocrinology Service 7D, 20307, Washington, DC, USA aut NATIONALLICENCE 700 1- Cerletty J. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Elliott W. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Lemann Jr J. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Gray R. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Eil C. Department of Medicine, Roger Williams Hospital, Brown University School of Medicine, 02908, Providence, RI, USA aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/5(1990-05-01), 407-413 0391-4097 13:5<407 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer