caa a22 4500 465805396 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF03350690 doi (NATIONALLICENCE)springer-10.1007/BF03350690 Circulating somatostatin after oral glucose in hypothyroidism [Elektronische Daten] [A. Kung, K. Lam, K. Pun, C. Wang, R. Yeung] The response of circulating somato-statin-like immunoactivity (SLI) to oral glucose and its relation to other pancreatic islet cell hormones were studied in 10 hypothyroid subjects before and after treatment. None of the patients suffered from diabetes mellitus or obesity. Compared with normal controls, the hypothyroid subjects had higher fasting and stimulated SLI levels but lower fasting pancreatic glucagon levels. Integrated glucose and insulin responses following glucose ingestion were normal, but the peak insulin réponse was delayed to 120 min suggesting impaired pancreatic β-cell response to oral glucose. On the other hand, the peak response of plasma C-peptide was higher probably because of a reduction in metabolic clearance. In both hypothyroid subjects and controls, a significant correlation was found between the maximal increment of SLI and the maximal decrement of glucagon following oral glucose. In conclusion, plasma SLI is increased in hypothyroidism. The changes in SLI may be due to either an increased hormonal secretion or a reduced metabolic clearance in hypothyroidism. This elevated SLI might contribute to the slower gastrointestinal motility observed in hypothyroidism. Our data also suggest that the reduction in glucagon secretion may be secondary to the increase in circulating SLI. Italian Society of Endocrinology (SIE), 1990 Somatostatin nationallicence hypothyroidism nationallicence Kung A. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut Lam K. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut Pun K. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut Wang C. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut Yeung R. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut Journal of Endocrinological Investigation Springer International Publishing 13/5(1990-05-01), 403-406 0391-4097 13:5<403 1990 13 40618 https://doi.org/10.1007/BF03350690 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03350690 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kung A. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut NATIONALLICENCE 700 1- Lam K. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut NATIONALLICENCE 700 1- Pun K. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut NATIONALLICENCE 700 1- Wang C. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut NATIONALLICENCE 700 1- Yeung R. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/5(1990-05-01), 403-406 0391-4097 13:5<403 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer