caa a22 4500 465805450 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF03350693 doi (NATIONALLICENCE)springer-10.1007/BF03350693 Disappearance of thyroid-stimulation blocking antibody by glucocorticoid therapy in a patient with primary myxedema who developed aortitis syndrome during L-thyroxine supplementation [Elektronische Daten] [C. Shigemasa, T. Kouchi, S. Taniguchi, Y. Mitani, H. Mashiba] A 39-year-old woman with primary myxedema, who had the potent activities of thyrotropin-binding inhibitory immunoglobulins (TBII) and thyroid-stimulation blocking antibodies (TSBAb), developed aortitis syndrome about 6 months after the initiation of L-thyroxine (L-T4) supplementation. A 35 mg daily dose of prednisolone for aortitis syndrome was initiated, and the dose was gradually reduced. TBII and TSBAb activities were gradually decreased, and both reached normal levels (7.7% and 10.1%, respectively) 3 months after the initiation of prednisolone. Therefore, dose of L-T4 was gradually reduced, and L-T4 supplementation was stopped. Subsequently, however, recurrence of hypothyroidism was not observed. These observations indicate the possibility that hypothyroidism remits with disappearance of TBII and TSBAb activities in not only neonatal cases but also adult cases. Italian Society of Endocrinology (SIE), 1990 TSBAb nationallicence primary myxedema nationallicence L-T4 therapy nationallicence glucocorticoids nationallicence aortitis syndrome nationallicence remission of hypothyroidism nationallicence Shigemasa C. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut Kouchi T. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut Taniguchi S. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut Mitani Y. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut Mashiba H. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut Journal of Endocrinological Investigation Springer International Publishing 13/5(1990-05-01), 415-418 0391-4097 13:5<415 1990 13 40618 https://doi.org/10.1007/BF03350693 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03350693 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shigemasa C. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Kouchi T. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Taniguchi S. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Mitani Y. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Mashiba H. The First Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/5(1990-05-01), 415-418 0391-4097 13:5<415 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer