caa a22 4500 46580554X CHVBK 20180323112103.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF03349519 doi (NATIONALLICENCE)springer-10.1007/BF03349519 Comparison of RA 131I treatment protocols for Graves' disease [Elektronische Daten] [L. DeGroot, A. Mangklabruks, M. McCormick] The efficacy of 131I therapy in achieving euthyroidism has been studied in a group of 264 patients followed for up to 10 yr. One hundred and eighty-six were given a dose adjusted for thyroid size and radioactive iodine uptake (Protocol 1), and a second group received the same dosage followed by antithyroid drug therapy plus potassium iodide for 15 days (Protocol 2). At 10-yr follow-up, 50-60% of patients were euthyroid. 25-29% of patients required 2 doses of 131I, and 4-5% required 3 doses. Fewer patients became hypothyroid when their pretreatment FTI was above the average value. More patients became hypothyroid, if their pretreatment test for antimic-rosomal antibodies was positive. Patients who required a second dose of radioactive iodide had a significantly greater chance of having worsening of their ophthalmopathy than those who became hypothyroid after the first dose. Treatment with radioactive iodide under either protocol appears to achieve euthyroidism at 10 yr with an incidence higher than that achieved by antithyroid drugs and comparable to that reported for subtotal thyroidectomy. Italian Society of Endocrinology (SIE), 1990 Antithyroid drug therapy nationallicence euthyroidism nationallicence exophthalmos nationallicence hyperthyroidism nationallicence hypothyroidism nationallicence radioactive iodine therapy nationallicence surgery nationallicence thyrotoxicosis nationallicence DeGroot L. Thyroid Study Unit, The University of Chicago, 5841 South Maryland Avenue, Box 138, 60637, Chicago, IL, USA aut Mangklabruks A. aut McCormick M. aut Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 111-118 0391-4097 13:2<111 1990 13 40618 https://doi.org/10.1007/BF03349519 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349519 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DeGroot L. Thyroid Study Unit, The University of Chicago, 5841 South Maryland Avenue, Box 138, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Mangklabruks A. aut NATIONALLICENCE 700 1- McCormick M. aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 111-118 0391-4097 13:2<111 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer