caa a22 4500 465805574 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF03349536 doi (NATIONALLICENCE)springer-10.1007/BF03349536 Modulation of lymphoid cell sensitivity to interferon by thyroid hormones [Elektronische Daten] [Mauro Provinciali, N. Fabris] The possibility of increasing the responsiveness of lymphoid cells to Interferon (IFN) was investigated by studying the effect of the in vitro preincubation of spleen cells from young mice with thyroid hormone prior to the administration of IFN on their Natural Killer (NK) activity. Both physiological concentrations of T4 or T3 are able to significantly increase the boosting action of IFN on NK cells. The increase in IFN-respon-siveness is observable at various IFN concentrations and the peak level of IFN-induced NK activity is reached with less than a half-optimal IFN concentration after T4 pretreatment. The effect of T4 on the IFN-sensitivity of NK cells requires a very short time, being already fully expressed after only 30 min, with minor increments at more prolonged incubation times. These results indicate for the first time the possibility of modulating the in vitro sensitivity to IFN by a hormonal approach. Italian Society of Endocrinology (SIE), 1990 Thyroid hormones nationallicence Natural Killer Activity nationallicence interferon nationallicence mice nationallicence Provinciali Mauro Centro di Immunologia, Dipartimento di Gerontologia, INRCA, Via Birarelli 8, 60100, Ancona, Italy aut Fabris N. Centro di Immunologia, Dipartimento di Gerontologia, INRCA, Via Birarelli 8, 60100, Ancona, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 187-191 0391-4097 13:2<187 1990 13 40618 https://doi.org/10.1007/BF03349536 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349536 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Provinciali Mauro Centro di Immunologia, Dipartimento di Gerontologia, INRCA, Via Birarelli 8, 60100, Ancona, Italy aut NATIONALLICENCE 700 1- Fabris N. Centro di Immunologia, Dipartimento di Gerontologia, INRCA, Via Birarelli 8, 60100, Ancona, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 187-191 0391-4097 13:2<187 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer