caa a22 4500 465805655 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF03349522 doi (NATIONALLICENCE)springer-10.1007/BF03349522 Atrial natriuretic peptide in Cushing's disease [Elektronische Daten] [G. Opocher, S. Rocco, G. Carpenè, F. Pedini, M. Scarante, R. Milani, M. Boscaro, F. Mantero] Atrial Natriuretic Peptide (ANF), is secreted by atrial myocytes in response to atrial stretch. Its plasma levels have been found elevated in conditions leading to salt and fluid repletion and consequent atrial distention. Recently, it has been demonstrated that dexamethasone can enhance ANF secretion, by acting on ANF gene expression and mRNA synthesis. High plasma levels of ANF have been observed in normal man after administration of Cortisol and ACTH. In the case of glucocorticoid excess, as in Cushing's disease, limited and conflicting data are available. Therefore, we measured ANF basal values and ANF response to postural changes and volume expansion in eight patients with Cushing's disease. In our patients ANF values were higher than normals. ANF responded to volume expansion, 47.8 ± 5.1 pg/ml before sodium load and 69.9 ± 7.0 pg/ml after sodium load, and changed minimally after postural manoeuvres, 47.3 ± 3.2 pg/ml supine and 41.7 ± 5.1 pg/ml upright. These data indicate that ANF secretion is enhanced in Cushing's disease, and its regulation is partially altered. Since in this condition hypervolemia has not been certainly demonstrated, a direct relationship between elevated ANF and glucocorticoid excess could be suggested. Italian Society of Endocrinology (SIE), 1990 ANF nationallicence Cushing's disease nationallicence Cortisol nationallicence adrenal cortex nationallicence Opocher G. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut Rocco S. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut Carpenè G. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut Pedini F. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut Scarante M. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut Milani R. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut Boscaro M. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut Mantero F. Istituto di Clinica Medica III, Università di Catania, 95100, Catania, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 133-137 0391-4097 13:2<133 1990 13 40618 https://doi.org/10.1007/BF03349522 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349522 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Opocher G. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Rocco S. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Carpenè G. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Pedini F. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Scarante M. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Milani R. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Boscaro M. Istituto di Semeiotica Medica, Università di Padova, via Ospedate 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Mantero F. Istituto di Clinica Medica III, Università di Catania, 95100, Catania, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 133-137 0391-4097 13:2<133 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer