caa a22 4500 465805663 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF03349530 doi (NATIONALLICENCE)springer-10.1007/BF03349530 Thyroid dysfunction in a prospectively followed series of patients with progressive systemic sclerosis [Elektronische Daten] [L. De Keyser, D. Narhi, D. Furst, A. Huberman, R. Ross, J. Clements, A. Van Herle] Thirty-nine patients with progressive systemic sclerosis (PSS) in stable clinical conditions were extensively evaluated for the presence of thyroid disease. Two patients had previously undetected hypothyroidism while 7 additional patients had normal serum thyroid hormone levels but an exaggerated TSH response to thyrotropin -releasing hormone (TRH) administration, consistent with subclinical hypothyroidism. Four of the 9 subjects with abnormal TRH responses had positive antithyroid antibodies and of the remaining 5, 4 had been on chlorambucil or prednisone. Basal TSH and TSH response to TRH were significantly higher in PSS patients as a group when compared to a control group and increased with increasing duration of PSS. Serum antithyroid antibodies (an-tithyroglobulin and/or antimicrosomal antibodies) were positive in 18% and thyroid scans were abnormal in 18% of the patients. The euthyroid sick syndrome was not seen. Our findings indicate an increased frequency of, sometimes previously unsuspected, clinical and subclinical hypothyroidism in stable PSS patients which appears to be autoimmune in nature and becomes more prevalent with increased PSS duration. Careful and regular monitoring of the thyroid function in PSS patients is advisable. Italian Society of Endocrinology (SIE), 1990 Connective tissue disease nationallicence progressive systemic sclerosis nationallicence thyroid function nationallicence TRH-test nationallicence De Keyser L. UCLA Department of Medicine, Division of Endocrinology, UCLA School of Medicine, USA aut Narhi D. Department of Radiology, Los Angeles, California, USA aut Furst D. UMSNJ, New Brunswick, N.J., USA aut Huberman A. Department of Radiology, Los Angeles, California, USA aut Ross R. Division of Nuclear Medicine, Los Angeles, California, USA aut Clements J. Department of Radiology, Los Angeles, California, USA aut Van Herle A. UCLA Department of Medicine, Division of Endocrinology, UCLA School of Medicine, USA aut Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 161-169 0391-4097 13:2<161 1990 13 40618 https://doi.org/10.1007/BF03349530 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349530 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Keyser L. UCLA Department of Medicine, Division of Endocrinology, UCLA School of Medicine, USA aut NATIONALLICENCE 700 1- Narhi D. Department of Radiology, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Furst D. UMSNJ, New Brunswick, N.J., USA aut NATIONALLICENCE 700 1- Huberman A. Department of Radiology, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Ross R. Division of Nuclear Medicine, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Clements J. Department of Radiology, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Van Herle A. UCLA Department of Medicine, Division of Endocrinology, UCLA School of Medicine, USA aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 161-169 0391-4097 13:2<161 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer