caa a22 4500 465805698 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF03349513 doi (NATIONALLICENCE)springer-10.1007/BF03349513 A study of pineal-prolactin interaction: prolactin response to an acute melatonin injection in patients with hyperprolactinemia [Elektronische Daten] [P. Lissoni, E. Mainini, C. Mazzi, G. Cattaneo, S. Barni] Several studies demonstrated that the pineal gland plays a regulatory role on PRL secretion. At present, however, there are few clinical data only about the pineal function in PRL secretion disorders. To further clarify which is the pineal importance in the dysfunctions of PRL release, we have evaluated the effect of an acute injection of the pineal hormone melatonin in 19 patients with hyperprolactinemia, 8 of whom had idiopathic hyperprolactinemia, while the other 11 had a prolactinoma. Melatonin was given im at a dose of 20 mg at 09:00 h, and venous blood samples were collected at — 20, 0, 20, 60, 120, 180 min. A normalization of PRL levels was achieved after melatonin injection in 3/8 patients with idiopathic hyperprolactinemia, while no effect was seen in patients with prolactinoma. Further studies, by evaluating the effect of a chronic treatment, will be required to define which is the action of melatonin on PRL release in PRL secretion disorders, and to evaluate its possible therapeutic role. Italian Society of Endocrinology (SIE), 1990 Hyperprolactinemias nationallicence melatonin nationallicence pineal gland nationallicence prolactin nationallicence prolactinomas nationallicence Lissoni P. Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, 20052, Monza, Italy aut Mainini E. Divisione di Endocrinologia, Ospedale S. Antonio Abate, Gallarate, Italy aut Mazzi C. Divisione di Endocrinologia, Ospedale S. Antonio Abate, Gallarate, Italy aut Cattaneo G. Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, 20052, Monza, Italy aut Barni S. Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, 20052, Monza, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 85-89 0391-4097 13:2<85 1990 13 40618 https://doi.org/10.1007/BF03349513 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349513 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lissoni P. Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, 20052, Monza, Italy aut NATIONALLICENCE 700 1- Mainini E. Divisione di Endocrinologia, Ospedale S. Antonio Abate, Gallarate, Italy aut NATIONALLICENCE 700 1- Mazzi C. Divisione di Endocrinologia, Ospedale S. Antonio Abate, Gallarate, Italy aut NATIONALLICENCE 700 1- Cattaneo G. Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, 20052, Monza, Italy aut NATIONALLICENCE 700 1- Barni S. Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, 20052, Monza, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 85-89 0391-4097 13:2<85 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer