caa a22 4500 465805744 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF03349517 doi (NATIONALLICENCE)springer-10.1007/BF03349517 Contribution of thyroid ultrasound and serum calcitonin to the diagnosis of congenital hypothyroidism [Elektronische Daten] [J. Chanoine, V. Toppet, J. Body, G. Van Vliet, R. Lagasse, P. Bourdoux, M. Spehl, F. Delange] To elucidate the role of thyroid ultrasound (TU) in the diagnosis of congenital hypothyroidism (CH), we compared 1) TU and thyroid scintigraphy (TS) in 6 CH newborns and 2) TU results in the 6 CH newborns, in 8 newborns with "false positive” results at screening, in 13 CH children aged 2 mo to 12 yr treated since the neonatal period and in 235 controls aged 0-12 yr. Results: 1) In all 6 CH newborns with no thyroid uptake at TS, TU evidenced small posterior hyperechogenic masses in the thyroid area [Vol: 322 ± 180 (SD) mm3]; 2) In all normal controls and in the 8 "false positive” cases at screening TU showed normal thyroid structures. The thyroid volume was 831 ± 383 mm3 in normal newborns and progressively increased with age. In the older CH children, TU also demonstrated the hyperechogenic masses, but their volume barely increased with age: as a consequence, the difference between the volume of the masses in CH patients and the thyroid tissue in controls, already significant in newborns (p < 0.01), markedly increased with age. The exact nature of these masses is unknown; they could represent poorly vascularized ultimobranchial remnants containing the calcitonin — secreting cells: this hypothesis is supported by our finding that serum concentrations of calcitonin (measured by a sensitive extraction method) (mean ± SD, pg/ml) were lower in the CH patients (2.9 ± 1.5) than in controls (13.0 ± 6.9; p < 0.001) at birth. In conclusion, in all cases of CH, TU showed abnormal structures in the thyroid area. TU and TS provide complementary information in the diagnosis of CH, and TU should be routinely performed in all newborns suspected of CH to avoid unnecessary use of TS in unaffected infants. Italian Society of Endocrinology (SIE), 1990 Congenital hypothyroidism nationallicence thyroid ultrasound nationallicence calcitonin nationallicence Chanoine J. Department of Pediatrics, Hôpital Universitaire des Enfants, 15, Rue J. CROCO, B 1020, Brussels, Belgium aut Toppet V. Department of Radiology, Hospital Saint-Pierre, Belgium aut Body J. Department of Medicine, Institut J. Bordet, Belgium aut Van Vliet G. Department of Pediatrics, Hôpital Universitaire des Enfants, 15, Rue J. CROCO, B 1020, Brussels, Belgium aut Lagasse R. Ecole de Santé Publique, Université Libre de Bruxelles, Bruxelles, Belgium aut Bourdoux P. Department of Radioisotopes, Hospital Saint-Pierre, Belgium aut Spehl M. Department of Radiology, Hospital Saint-Pierre, Belgium aut Delange F. Department of Pediatrics, Hôpital Universitaire des Enfants, 15, Rue J. CROCO, B 1020, Brussels, Belgium aut Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 103-109 0391-4097 13:2<103 1990 13 40618 https://doi.org/10.1007/BF03349517 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349517 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chanoine J. Department of Pediatrics, Hôpital Universitaire des Enfants, 15, Rue J. CROCO, B 1020, Brussels, Belgium aut NATIONALLICENCE 700 1- Toppet V. Department of Radiology, Hospital Saint-Pierre, Belgium aut NATIONALLICENCE 700 1- Body J. Department of Medicine, Institut J. Bordet, Belgium aut NATIONALLICENCE 700 1- Van Vliet G. Department of Pediatrics, Hôpital Universitaire des Enfants, 15, Rue J. CROCO, B 1020, Brussels, Belgium aut NATIONALLICENCE 700 1- Lagasse R. Ecole de Santé Publique, Université Libre de Bruxelles, Bruxelles, Belgium aut NATIONALLICENCE 700 1- Bourdoux P. Department of Radioisotopes, Hospital Saint-Pierre, Belgium aut NATIONALLICENCE 700 1- Spehl M. Department of Radiology, Hospital Saint-Pierre, Belgium aut NATIONALLICENCE 700 1- Delange F. Department of Pediatrics, Hôpital Universitaire des Enfants, 15, Rue J. CROCO, B 1020, Brussels, Belgium aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 103-109 0391-4097 13:2<103 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer