caa a22 4500 465805752 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF03349528 doi (NATIONALLICENCE)springer-10.1007/BF03349528 Concentrations of somatomedin-C and triiodothyronine in patients with thyroid dysfunction and nonthyroidal illnesses [Elektronische Daten] [Matti Välimäki, Liewendahl,, S. Karonen, T. Helenius, A. Suikkari] We studied the possibility of an association between serum somatomedin-C (Sm-C) and thyroid hormone concentrations. For this purpose 34 hyperthyroid patients, 39 patients with primary hypothyroidism, 36 patients with severe nonthyroidal illnesses (NTI), and 63 euthyroid healthy control subjects were examined. The mean concentration of serum dialyzable free triiodothyronine (FT3) was 26.6 ± 15.4 pmol/l (± SD) in hyperthyroidism, 2.8 ± 1.2 in hypothyroidism, 4.2 ±1.1 in NTI, and 5.3 ± 0.7 in controls. The lowest mean concentration of serum Sm-C (10.1 + 3.0 nmol/l) was found in the NTI group and the highest in the hyperthyroid group (16.8 ± 3.2): these concentrations differed significantly from the mean control level (12.2 ± 2.2). In NTI patients the serum FT3 and T3 levels correlated significantly with the serum Sm-C levels (r = 0.63; p < 0.001, r = 0.65; p < 0.001, respectively). In hypothyroid patients there was a weak correlation between the serum FT3 and Sm-C levels (r = 0.36; p < 0.05), but no correlations were found in hyperthyroid and healthy subjects. We conclude that the lowered Sm-C levels in NTI do not reflect a hypothyroid state, as normal Sm-C levels were found in hypothyroidism, and that impaired nutritional state of the patients is the most likely explanation for the association between Sm-C and FT3 (and T3) in NTI. Italian Society of Endocrinology (SIE), 1990 Somatomedin-C nationallicence thyroid hormones nationallicence nonthyroidal illnesses nationallicence hyperthyroidism nationallicence hypothyroidism nationallicence Välimäki Matti Third Department of Medicine, University of Helsinki, Meilahti Hospital, SF-00290, Helsinki, Finland aut Liewendahl, Department of Clinical Chemistry, Helsinki, Finland aut Karonen S. Department of Clinical Chemistry, Helsinki, Finland aut Helenius T. Minerva Foundation Institute, Helsinki, Finland aut Suikkari A. First Department of Obstetrics and Gynecology, University of Helsinki, Finland aut Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 155-159 0391-4097 13:2<155 1990 13 40618 https://doi.org/10.1007/BF03349528 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349528 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Välimäki Matti Third Department of Medicine, University of Helsinki, Meilahti Hospital, SF-00290, Helsinki, Finland aut NATIONALLICENCE 700 1- Liewendahl Department of Clinical Chemistry, Helsinki, Finland aut NATIONALLICENCE 700 1- Karonen S. Department of Clinical Chemistry, Helsinki, Finland aut NATIONALLICENCE 700 1- Helenius T. Minerva Foundation Institute, Helsinki, Finland aut NATIONALLICENCE 700 1- Suikkari A. First Department of Obstetrics and Gynecology, University of Helsinki, Finland aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 155-159 0391-4097 13:2<155 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer