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   <subfield code="a">Morning to evening changes of human pituitary and adrenal responses to specific stimuli</subfield>
   <subfield code="h">[Elektronische Daten]</subfield>
   <subfield code="c">[M. Terzolo, A. Piovesan, G. Osella, B. Puligheddu, M. Torta, P. Paccotti, Alberto Angeli]</subfield>
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   <subfield code="a">We performed a combined stimulation test with the simultaneous application of GnRH (100 μg), TRH (200 μg) and ACTH (10 μg) in 10 healthy adult males at two opposite clock timing, i.e. at 09:00 and 21:00 h. Pituitary (gonadotropins, PRL, TSH) and adrenal (Cortisol, aldosterone, progesterone) hormones showed a common trend of enhanced responsiveness to the evening challenge. Differences reached statistical significance in the case of Cortisol, aldosterone, PRL and FSH. These findings suggest that the responsiveness of some pituitary and adrenocortical hormones to specific stimuli is physiologically different in humans as a function of the clock timing, being higher in the evening than in the morning. From the clinical standpoint, however, differences in the magnitude of responses were not enough to recommend provocative testing at a particular clock time, at least for routine diagnostic purposes.</subfield>
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   <subfield code="a">Italian Society of Endocrinology (SIE), 1990</subfield>
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   <subfield code="a">circadian rhythms</subfield>
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   <subfield code="u">Dipartimento di Biomedicina, Cattedra di Patologia Speciale Medica, Università degli Studi di Torino, Ospedale S. Luigi, Regione Gonzole 10, 10043, Orbassano, Italy</subfield>
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