caa a22 4500 465805795 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF03349521 doi (NATIONALLICENCE)springer-10.1007/BF03349521 Effect of pulsatile luteinizing hormone — releasing hormone administration on pituitary — gonadal function in elderly man [Elektronische Daten] [Massimo Giusti, G. Marini, L. Traverso, P. Cavagnaro, L. Granziera, G. Giordano] The effect of short-term pulsatile LHRH administration was studied in 8 healthy subjects ranging from 60 to 81 yr to see if the decrease of pituitary gonadal function could be in part due to changes in the discharge of LHRH from the hypothalamus. Gonadotropin and testosterone (T) secretion was evaluated two weeks before and during LHRH (122-160 ng/kg bw every 120 min sc) infusion. In addition, a bolus dosage of LHRH (50 μ iv) was given both at the beginning and at the end of pulsatile LHRH administration in order to test gonadotrophs sensitivity. A significant increase in gonadotropin levels from day 0 to day 4 was found, and was followed by a subsequent decrease from day 7 to day 14. A slight significant increase in T levels was observed during LHRH administration (p < 0.01). LH pulses were identified in 5 out of 8 subjects on day 0. On day 14, all the exogenous LHRH pulses were followed by significant LH bursts. There was not a significant decrease in the pituitary LH responsiveness to LHRH test from day 0 to day 14. Our study seems to indicate that pituitary — gonadal unit in normal elderly men can be modulated by pulsatile administration of LHRH. A pulse frequency of LHRH which is probably similar to the physiological one, could induce a slight increase in T levels via qualitative changes in LH activity. We can assume that clinical changes in gondadal activity might also be connected to some disturbances in endogenous LHRH pulsar. Italian Society of Endocrinology (SIE), 1990 LHRH nationallicence pulsatile administration nationallicence LH nationallicence testosterone nationallicence elderly man nationallicence Giusti Massimo I.S.M.I. Cattedra di Endocrinologia, Universita di Genova, Viale Benedetto XV, 6, 16100, Genova, Italy aut Marini G. Casa di Riposo di Genova, Medical Systems, 16100, Genova, Italy aut Traverso L. I.S.M.I. Cattedra di Endocrinologia, Universita di Genova, Viale Benedetto XV, 6, 16100, Genova, Italy aut Cavagnaro P. I.S.M.I. Cattedra di Endocrinologia, Universita di Genova, Viale Benedetto XV, 6, 16100, Genova, Italy aut Granziera L. Ricerca e Sviluppo, Medical Systems, 16100, Genova, Italy aut Giordano G. I.S.M.I. Cattedra di Endocrinologia, Universita di Genova, Viale Benedetto XV, 6, 16100, Genova, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 127-132 0391-4097 13:2<127 1990 13 40618 https://doi.org/10.1007/BF03349521 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349521 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giusti Massimo I.S.M.I. Cattedra di Endocrinologia, Universita di Genova, Viale Benedetto XV, 6, 16100, Genova, Italy aut NATIONALLICENCE 700 1- Marini G. Casa di Riposo di Genova, Medical Systems, 16100, Genova, Italy aut NATIONALLICENCE 700 1- Traverso L. I.S.M.I. Cattedra di Endocrinologia, Universita di Genova, Viale Benedetto XV, 6, 16100, Genova, Italy aut NATIONALLICENCE 700 1- Cavagnaro P. I.S.M.I. Cattedra di Endocrinologia, Universita di Genova, Viale Benedetto XV, 6, 16100, Genova, Italy aut NATIONALLICENCE 700 1- Granziera L. Ricerca e Sviluppo, Medical Systems, 16100, Genova, Italy aut NATIONALLICENCE 700 1- Giordano G. I.S.M.I. Cattedra di Endocrinologia, Universita di Genova, Viale Benedetto XV, 6, 16100, Genova, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/2(1990-02-01), 127-132 0391-4097 13:2<127 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer