caa a22 4500 465805817 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF03349646 doi (NATIONALLICENCE)springer-10.1007/BF03349646 Increase in antimicrosomal antibody-related lgG1 and lgG4, and titers of antithyroid peroxidase antibodies, but not antibody dependent cell-mediated cytotoxicity in post-partum thyroiditis with transient hyperthyroidism [Elektronische Daten] [R. Briones-Urbina, A. Parkes, U. Bogner, S. Mariotti, P. Walfish] To evaluate possible immunological mechanisms involved in the development of postpartum thyroiditis with transient hyperthyroidism followed by transient hypothyroidism (PPT), antithyroid peroxidase antibodies (anti-TPO), antimicrosomal antibody (AMA) related immunoglobin G subclass and antibody-dependent cell-mediated cytotoxicity (ADCC) were studied in 43 post-partum (PP) women who were euthyroid at delivery and completed a subsequent 1 year follow up. Among the 25 mothers who developed PPT, 14 had positive AMA (PPT:AMA+) and 11 negative AMA (PPT:AMA-) at delivery. Among the 18 mothers who remained euthyroid (E) up to one year post-partum and were used as controls, 8 were AMA positive (E:AMA+) and 10 AMA negative (E:AMA-) at delivery. AMA measured by a hemagglutination method correlated well with anti-TPO antibodies measured by RIA in the PP mothers studied. When AMA-related IgG subclass activity was analysed comparing PPT women with appropriate euthyroid controls at the different time intervals studied, it was seen that PPT:AMA+ when compared to E:AMA+ women have significantly increased activity of AMA related IgG1 at all PP time intervals studied (p<0.001), but lgG4 was only increased at 5-7 months PP (p<0.05). PPT:AMA-when compared to E:AMA-have significantly increased lgG4 at 2-4 (p<0.001), 5-7 and 1-12 (p<0.05) months PP, but lgG1 is only increased at 5-7 months PP (p<0.05). The development of PPT coincides with an increase in activity in AMA related lgG1 and lgG4 in all groups with a lesser increase in AMA related lgG2 for PPT:AMA+, thereby documenting a variable polyclonal IgG subclass antibody response in those women who develop PPT. The studies in ADCC failed to demonstrate any differences in women with PPT compared to euthyroid PP controls. In conclusion, these observations appear to indicate that AMA and anti-TPO are more likely markers rather than etiological factors for the development of PPT. As well, they suggest that the destructive hyperthyroidism of PPT may not be mediated by ADCC but may involve different as yet unidentified cytotoxic mechanisms. Italian Society of Endocrinology (SIE), 1990 Antithyroid nationallicence antimicrosomal nationallicence IgG Subclasses nationallicence antibody dependent cell-mediated nationallicence cytotoxicity nationallicence post-partum thyroiditis nationallicence Briones-Urbina R. Mount Sinai Hospital, University of Toronto, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada aut Parkes A. Department of Medicine, University of Wales College of Medicine, Cardiff, Wales, UK aut Bogner U. Free University of Berlin, FRG aut Mariotti S. Istituto di Endocrinologia, University of Pisa, Pisa, Italy aut Walfish P. Mount Sinai Hospital, University of Toronto, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada aut Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 879-886 0391-4097 13:11<879 1990 13 40618 https://doi.org/10.1007/BF03349646 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349646 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Briones-Urbina R. Mount Sinai Hospital, University of Toronto, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Parkes A. Department of Medicine, University of Wales College of Medicine, Cardiff, Wales, UK aut NATIONALLICENCE 700 1- Bogner U. Free University of Berlin, FRG aut NATIONALLICENCE 700 1- Mariotti S. Istituto di Endocrinologia, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Walfish P. Mount Sinai Hospital, University of Toronto, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 879-886 0391-4097 13:11<879 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer