caa a22 4500 465805892 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF03349663 doi (NATIONALLICENCE)springer-10.1007/BF03349663 Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil [Elektronische Daten] [C. Hayashida, A. Duarte, A. Sato, E. Yamashiro-Kanashiro] A female newborn whose mother was taking propylthiouracil (PTU) for Graves' disease, presented with transient thyrotoxicosis (serum triiodothyronine 1,710 ng/dl) and signs of acute hepatic injury. Jaundice and choluria were evident on her fourth day of life. Serum total bilirubin reached 14 mg/dl, with a direct fraction of 11 mg/dl. Serum alanine aminotransferase and aspartate aminotransferase showed moderate elevations (110 IU/I and 61.5 IU/I, respectively), as well as the alkaline prosphatase which increased to about twice the upper limit of normal. When incubated with PTU, the patient's cultured peripheral lymphocytes underwent transformation to more than twice the values found in 2 controls, with a stimulation index (SI) of 3.19, compared to SI of 1.45 and 1.15 for the controls, suggesting a hypersensitivity mechanism involved in the hepatic injury. Although about 20 cases of PTU induced hepatic damage were reported in the medical literature, this is, as far as we know, the first description of neonatal liver injury probably caused by placental transfer of this drug. Italian Society of Endocrinology (SIE), 1990 Propylthiouracil nationallicence hepatitis nationallicence maternal-fetal exchange nationallicence lymphocyte transformation nationallicence Hayashida C. Department of Medicine, Division of Endocrinology, School of Medicine, São Paulo University, Av. Dr. Arnaldo 455/715, SP CEP 01246, São Paulo, Brasil aut Duarte A. Immunogenetics and Experimental Transplantation Laboratory, School of Medicine, São Paulo University, Brasil aut Sato A. Unit of Neonatology, Hospital e Maternidade Leonor Mendes de Barros, São Paulo, Brasil aut Yamashiro-Kanashiro E. Immunogenetics and Experimental Transplantation Laboratory, School of Medicine, São Paulo University, Brasil aut Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 937-941 0391-4097 13:11<937 1990 13 40618 https://doi.org/10.1007/BF03349663 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349663 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hayashida C. Department of Medicine, Division of Endocrinology, School of Medicine, São Paulo University, Av. Dr. Arnaldo 455/715, SP CEP 01246, São Paulo, Brasil aut NATIONALLICENCE 700 1- Duarte A. Immunogenetics and Experimental Transplantation Laboratory, School of Medicine, São Paulo University, Brasil aut NATIONALLICENCE 700 1- Sato A. Unit of Neonatology, Hospital e Maternidade Leonor Mendes de Barros, São Paulo, Brasil aut NATIONALLICENCE 700 1- Yamashiro-Kanashiro E. Immunogenetics and Experimental Transplantation Laboratory, School of Medicine, São Paulo University, Brasil aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 937-941 0391-4097 13:11<937 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer