caa a22 4500 465805906 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF03349653 doi (NATIONALLICENCE)springer-10.1007/BF03349653 The growth hormone secretory response to fentanyl in rat: an involvement of μ type receptors [Elektronische Daten] [J. Govaerts, P. Buydens, E. Finné, A. Matton, L. Vanhaelst] Fentanyl, a selective μ opioid receptor agonist, administered intravenously, influences growth hormone secretion in conscious male rats. A dose-response study demonstrated that the maximum growth hormone release was obtained with 10 μg/kg while higher doses were less or not effective. MR-2266 (6 mg/kg iv), a μ and κ opioid receptor antagonist, and bremazocine (0.1 mg/kg iv) a μ opioid receptor antagonist with κ agonistic properties, both potently inhibited the growth hormone response to fentanyl (10 μg/κg iv). In contrast, the effect of fentanyl on growth hormone release was not blocked in rats treated with either ICI-154129 (30 mg/kg iv or 150 μg/kg intracerebroventricularly a selective δ opioid receptor antagonist, or U-50488 (10 mg/kg iv), a specific κ opioid receptor agonist. These results suggest that opioid receptors of the μ type are involved in the fentanyl-induced growth hormone release. Italian Society of Endocrinology (SIE), 1990 growth hormone nationallicence fentanyl nationallicence mu-receptors nationallicence Govaerts J. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut Buydens P. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut Finné E. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut Matton A. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut Vanhaelst L. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 911-915 0391-4097 13:11<911 1990 13 40618 https://doi.org/10.1007/BF03349653 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349653 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Govaerts J. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Buydens P. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Finné E. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Matton A. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Vanhaelst L. Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free Univérsity of Brussels (V.U.B.), Laarbeeklaan 103, B-1090, Brussels, Belgium aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 911-915 0391-4097 13:11<911 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer