caa a22 4500 465805914 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF03349651 doi (NATIONALLICENCE)springer-10.1007/BF03349651 Dyshormonogenetic goiter: presence of an inhibitor of normal human thyroid peroxidase [Elektronische Daten] [D. Rosenthal, D. Carvalho-Guimarães, M. Knobel, G. Medeiros-Neto] A dialyzable, thermostable inhibitor of normal thyroid peroxidase (TPO), with UV absorption maximum at 250-260 nm, was found in the digitonized, washed particulate fraction of two dyshormonogenetic goiters. No intrinsic TPO iodide-oxidation activity was detectable in either of these goiters, and their TPO iodination activity was below the method sensitivity threshold, even after dialysis. These findings could be explained by an absent or abnormal TPO associated with the synthesis of a TPO-inhibitor, or by the irreversible inhibition of a normal enzyme by the inhibitor. Italian Society of Endocrinology (SIE), 1990 Thyroid gland nationallicence dyshormonogenetic goiter nationallicence thyroid peroxidase nationallicence peroxidase inhibitor nationallicence hypothyroidism nationallicence Rosenthal D. Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949, Rio de Janeiro, Brasil aut Carvalho-Guimarães D. Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949, Rio de Janeiro, Brasil aut Knobel M. Laboratório de Tireóide, Hospital das Clínicas, Universidade de São Paulo, 05403, São Paulo, Brasil aut Medeiros-Neto G. Laboratório de Tireóide, Hospital das Clínicas, Universidade de São Paulo, 05403, São Paulo, Brasil aut Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 901-904 0391-4097 13:11<901 1990 13 40618 https://doi.org/10.1007/BF03349651 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349651 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosenthal D. Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949, Rio de Janeiro, Brasil aut NATIONALLICENCE 700 1- Carvalho-Guimarães D. Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949, Rio de Janeiro, Brasil aut NATIONALLICENCE 700 1- Knobel M. Laboratório de Tireóide, Hospital das Clínicas, Universidade de São Paulo, 05403, São Paulo, Brasil aut NATIONALLICENCE 700 1- Medeiros-Neto G. Laboratório de Tireóide, Hospital das Clínicas, Universidade de São Paulo, 05403, São Paulo, Brasil aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 901-904 0391-4097 13:11<901 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer