caa a22 4500 465805949 CHVBK 20180323112103.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF03349644 doi (NATIONALLICENCE)springer-10.1007/BF03349644 Evaluation of clinical and hormonal effects in hirsute women treated with ketoconazole [Elektronische Daten] [J. Conget, I. Halperin, J. Ferrer, J. González-Clemente, M. Martinez-Osaba, E. Vilardell] Seven hirsute women were treated with 200 mg/12 h po of ketoconazole during 6 months. We evaluated clinical and hormonal effects during this period. Ketoconazole treatment decreased testosterone, androstenedione and dehydroepiandrosterone sulfate, while 17-alfahydroxyprogesterone increased. This finding suggests a steroidogenic blockade at the level of C17-20 lyase. We did not observe changes in LH, SHBG and Cortisol values. In spite of this findings after 6 months treatment, hirsutism remained unmodified. We conclude that ketoconazole inhibits androgen synthesis in hirsute women, but the use of this drug as an alternative and effective treatment of hirsutism warrants further evaluation. Italian Society of Endocrinology (SIE), 1990 Hirsutism nationallicence hormonal effects nationallicence clinical effects nationallicence ketoconazole nationallicence Conget J. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Halperin I. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Ferrer J. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut González-Clemente J. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Martinez-Osaba M. Hormonology Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Vilardell E. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 867-870 0391-4097 13:11<867 1990 13 40618 https://doi.org/10.1007/BF03349644 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349644 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Conget J. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Halperin I. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Ferrer J. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- González-Clemente J. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Martinez-Osaba M. Hormonology Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Vilardell E. Endocrinology and Nutrition Service, Hospital Clinic, Universidad de Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 867-870 0391-4097 13:11<867 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer