caa a22 4500 465805981 CHVBK 20180323112104.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF03349657 doi (NATIONALLICENCE)springer-10.1007/BF03349657 Cyclical Cushing's disease and its successful control under sodium valproate [Elektronische Daten] [A. Beckers, A. Stevenaert, G. Pirens, P. Flandroy, J. Sulon, G. Hennen] Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of Cortisol, presence or absence of response after GRH or TRH, cyclical Cushing's disease). We present here a detailed case report on a patient suffering from Cushing's disease whose endocrine functions were extensively investigated. Treatment with bromocriptine, as well;as subsequent transsphenoidal surgery, were followed by rapid but transient reversal of symptoms. When clinical manifestations reoccurred, daily measurements of free urinary Cortisol revealed a cyclic pattern of Cortisol hyperexcretion. A study of ultradian rhythm revealed hyperpulsatility of Cortisol secretion. More interestingly, a treatment with sodium valproate, a drug known to inhibit CRH production, was followed by a rapid and longstanding normalization of clinical and biological data for 2 years. Based on these data, and on information from the literature, the present case of Cushing's disease exhibits characteristics suggesting a possible hypothalamic origin. Italian Society of Endocrinology (SIE), 1990 Cyclical Cushing's disease nationallicence sodium valproate nationallicence hypothalamus nationallicence Beckers A. Endocrinologie Centre Hospitalier Universitaire, Université de Liège, Sart-Tilman B23, 4000, Liège, Belgium aut Stevenaert A. Neurosurgery, Université de Liège, Sart Tilman B-23, B-4000, Liège, Belgium aut Pirens G. Endocrinologie Centre Hospitalier Universitaire, Université de Liège, Sart-Tilman B23, 4000, Liège, Belgium aut Flandroy P. Radiology, Université de Liège, Sart Tilman B-23, B-4000, Liège, Belgium aut Sulon J. Endocrinologie Centre Hospitalier Universitaire, Université de Liège, Sart-Tilman B23, 4000, Liège, Belgium aut Hennen G. Endocrinologie Centre Hospitalier Universitaire, Université de Liège, Sart-Tilman B23, 4000, Liège, Belgium aut Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 923-929 0391-4097 13:11<923 1990 13 40618 https://doi.org/10.1007/BF03349657 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349657 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beckers A. Endocrinologie Centre Hospitalier Universitaire, Université de Liège, Sart-Tilman B23, 4000, Liège, Belgium aut NATIONALLICENCE 700 1- Stevenaert A. Neurosurgery, Université de Liège, Sart Tilman B-23, B-4000, Liège, Belgium aut NATIONALLICENCE 700 1- Pirens G. Endocrinologie Centre Hospitalier Universitaire, Université de Liège, Sart-Tilman B23, 4000, Liège, Belgium aut NATIONALLICENCE 700 1- Flandroy P. Radiology, Université de Liège, Sart Tilman B-23, B-4000, Liège, Belgium aut NATIONALLICENCE 700 1- Sulon J. Endocrinologie Centre Hospitalier Universitaire, Université de Liège, Sart-Tilman B23, 4000, Liège, Belgium aut NATIONALLICENCE 700 1- Hennen G. Endocrinologie Centre Hospitalier Universitaire, Université de Liège, Sart-Tilman B23, 4000, Liège, Belgium aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 923-929 0391-4097 13:11<923 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer