caa a22 4500 46580599X CHVBK 20180323112104.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF03349660 doi (NATIONALLICENCE)springer-10.1007/BF03349660 Acromegaly and thymic hyperplasia: a case report [Elektronische Daten] [N. Bazzoni, B. Ambrosi, M. Arosio, M. Barbareschi, M. Losa, G. Faglia] Growth hormone overproduction is characterized by increased size of visceral organs as well as growth of bone and soft tissues. We describe a case of a 23-year-old female acromegalic patient, who had been previously unsuccessfully operated upon by transsphenoidal pituitary surgery and then irradiated. In November 1987 a routine X-ray chest examination revealed a mediastinal mass, subsequently confirmed by CT scan. The patient underwent surgical removal of the mass: macroscopical aspect, histological sections and immunocytochemistry showed typical thymic structures without any evidence of neurosecretory activity. No GH-positive cells were found and only small amounts of immunoreactive GHRH like material (9.2 ng/g wet wg) were detected in the tumor extract. Before surgery plasma GHRH levels were not elevated (26 pg/ml); serum GH and IGF-I levels were 27.4 ± 4.9 μg/l and 191 nmol/l, respectively, and remained unchanged after surgery. These data ruled out a GHRH and/or GH ectopic production, confirming the primitive pituitary origin of acromegaly in this patient. It is likely that thymic hyperplasia may be explained by longstanding overproduction of GH and the young age of the patient. Italian Society of Endocrinology (SIE), 1990 Growth hormone nationallicence insulin-like growth factor-l nationallicence growth hormone releasing hormone nationallicence acromegaly nationallicence thymus nationallicence Bazzoni N. Istituto di Scienze Endocrine, University of Milano, Via F. Sforza 35, 20122, Milano, Italy aut Ambrosi B. Istituto di Scienze Endocrine, University of Milano, Via F. Sforza 35, 20122, Milano, Italy aut Arosio M. Istituto di Scienze Endocrine, University of Milano, Via F. Sforza 35, 20122, Milano, Italy aut Barbareschi M. 3a Cattedra di Anatomia Patologica e Istopatologia, University of Milano, 20122, Milano, Italy aut Losa M. Cattedra di Neurotraumatologia, Ospedale S. Raffaele, University of Milano, 20132, Milano, Italy aut Faglia G. Istituto di Scienze Endocrine, University of Milano, Via F. Sforza 35, 20122, Milano, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 931-935 0391-4097 13:11<931 1990 13 40618 https://doi.org/10.1007/BF03349660 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349660 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bazzoni N. Istituto di Scienze Endocrine, University of Milano, Via F. Sforza 35, 20122, Milano, Italy aut NATIONALLICENCE 700 1- Ambrosi B. Istituto di Scienze Endocrine, University of Milano, Via F. Sforza 35, 20122, Milano, Italy aut NATIONALLICENCE 700 1- Arosio M. Istituto di Scienze Endocrine, University of Milano, Via F. Sforza 35, 20122, Milano, Italy aut NATIONALLICENCE 700 1- Barbareschi M. 3a Cattedra di Anatomia Patologica e Istopatologia, University of Milano, 20122, Milano, Italy aut NATIONALLICENCE 700 1- Losa M. Cattedra di Neurotraumatologia, Ospedale S. Raffaele, University of Milano, 20132, Milano, Italy aut NATIONALLICENCE 700 1- Faglia G. Istituto di Scienze Endocrine, University of Milano, Via F. Sforza 35, 20122, Milano, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/11(1990-12-01), 931-935 0391-4097 13:11<931 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer