caa a22 4500 465811736 CHVBK 20180323112118.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02374740 doi (NATIONALLICENCE)springer-10.1007/BF02374740 Bone metabolic disorders caused by small bowel resection, and the influence of 1 α -hydroxyvitamin D3 on the rats [Elektronische Daten] [Hiroshi Uno, Yoshihiro Izawa, Tamotsu Koyama, Tomohiro Ohta, Tokutaro Makita, Mitsugi Sugiyama, Norimoto Urakawa] Metabolic bone disorders caused by resection of the distal three quarters of the small bowel and the effects of 1α-hydroxyvitamin D3 (1α(OH)D3) on the rats were investigated biochemically and histomorphologically. 1α(OH)D3 was administered orally to the rats for 13 weeks. A group of " sham operation” animals and the 75%-distal-small-bowel-resected control animals received only the vehicle. Bone changes developed 13 weeks after the partial bowel resection. The disorder was characterized by reductions in ash content of the femur and by the disappearance of the trabecular bone in tibial metaphysis. Decreased Ca absorption from the intestines was demonstrated by a radiotracer technique, and biochemical studies showed significant decreases in serum Ca and 1,25(OH)2D concentrations in the bowel-resected rats. These findings suggest that 75% distal small bowel resection impairs intestinal absorption of calcium and results in a negative calcium balance, which may contribute to the development of bone metabolic disorder in rats. This disorder was demonstrated as high bone turnover via urinalysis and by a radiotracer technique. Administration of 1α(OH)D3 increased dose-dependent Ca absorption from the intestine and the serum Ca, normalized the bone turnover rate and prevented the development of bone metabolic disorder. Japanese Society of Bone Metabolism Research, 1990 Small Bowel Resection nationallicence Bone Metabolic Disorder nationallicence 1 α -hydroxyvitamin D3 nationallicence Uno Hiroshi 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Izawa Yoshihiro 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Koyama Tamotsu 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Ohta Tomohiro 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Makita Tokutaro 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Sugiyama Mitsugi Second Department of Surgery, Yokohama City University School of Medicine, 3-46, Urafune-cho, Minamiku, 232, Yokohama, Japan aut Urakawa Norimoto Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College, 1-7-1 Kyonancho, Musashino, 180, Tokyo, Japan aut Journal of Bone and Mineral Metabolism Springer-Verlag 8/1(1990-04-01), 17-25 0914-8779 8:1<17 1990 8 774 https://doi.org/10.1007/BF02374740 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02374740 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uno Hiroshi 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Izawa Yoshihiro 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Koyama Tamotsu 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Ohta Tomohiro 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Makita Tokutaro 2ND Bio-Medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Sugiyama Mitsugi Second Department of Surgery, Yokohama City University School of Medicine, 3-46, Urafune-cho, Minamiku, 232, Yokohama, Japan aut NATIONALLICENCE 700 1- Urakawa Norimoto Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College, 1-7-1 Kyonancho, Musashino, 180, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer-Verlag 8/1(1990-04-01), 17-25 0914-8779 8:1<17 1990 8 774 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer