caa a22 4500 465811752 CHVBK 20180323112118.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02374739 doi (NATIONALLICENCE)springer-10.1007/BF02374739 Effect of 1α-hydroxyvitamin D3 on bone metabolic disorders in gastrectomized rats [Elektronische Daten] [Hiroshi Uno, Yoshihiro Izawa, Kiyoshi Sagara, Tamotsu Koyama, Tokutaro Makita, Chia-Yuan Hsu-Chang, Mitsugi Sugiyama] The effect of 1α-hydroxyvitamin D3 (1α(OH)D3) on the metabolic bone disorders developed in gastrectomized rats were investigated biochemically and histomorphologically. 1α(OH)D3 was suspended in 0.2 % Triton-X-100 aqueous solution after dissolving in a very small amount of ethanol, was given orally to the rats for 10 weeks. The sham operated animals and the gastrectomy control animals received the vehicle alone. Gastrectomy was followed by the development of the metabolic bone disorders after 10 weeks of observation. This was characterized by reduction in ash content of the femur and histologically by a disappearance of the trabecular bone in tibial metaphysis. Decrease Ca absorption from the intestines was demonstrated by a radiotracer technique. Biochemical studies showed significant decreases in serum 25(OH)D concentration in gastrectomized rats. These findings suggest that gastrectomy partially impairs intestinal absorption of calcium and results in a negative calcium balance, which may contribute to the development of bone metabolic disorders in rats. The administration of 1α(OH)D3 increased dose-dependently serum calcium and Ca absorption from the intestine and prevented the development of bone metabolic disorders histomorphologically. Japanese Society of Bone Metabolism Research, 1990 Gastrectomy nationallicence Bone Metabolic Disorder nationallicence 1 α -hydroxy vitamin D3 nationallicence Uno Hiroshi 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Izawa Yoshihiro 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Sagara Kiyoshi 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Koyama Tamotsu 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Makita Tokutaro 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut Hsu-Chang Chia-Yuan Second Department of Surgery, Yokohama City University School of Medicine, 3-46, Urafune-cho, Minami-ku, 232, Yokohama, Japan aut Sugiyama Mitsugi Second Department of Surgery, Yokohama City University School of Medicine, 3-46, Urafune-cho, Minami-ku, 232, Yokohama, Japan aut Journal of Bone and Mineral Metabolism Springer-Verlag 8/1(1990-04-01), 10-16 0914-8779 8:1<10 1990 8 774 https://doi.org/10.1007/BF02374739 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02374739 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uno Hiroshi 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Izawa Yoshihiro 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Sagara Kiyoshi 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Koyama Tamotsu 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Makita Tokutaro 2ND Bio-medical Research Laboratories, Teijin Limited, Hiroshi UNO, 4-3-2, Asahigaoka, Hino, 191, Tokyo, Japan aut NATIONALLICENCE 700 1- Hsu-Chang Chia-Yuan Second Department of Surgery, Yokohama City University School of Medicine, 3-46, Urafune-cho, Minami-ku, 232, Yokohama, Japan aut NATIONALLICENCE 700 1- Sugiyama Mitsugi Second Department of Surgery, Yokohama City University School of Medicine, 3-46, Urafune-cho, Minami-ku, 232, Yokohama, Japan aut NATIONALLICENCE 773 0- Journal of Bone and Mineral Metabolism Springer-Verlag 8/1(1990-04-01), 10-16 0914-8779 8:1<10 1990 8 774 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer