caa a22 4500 465812139 CHVBK 20180323112119.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03190128 doi (NATIONALLICENCE)springer-10.1007/BF03190128 Acetylator status of kwashiorkor children in Ibadan (South-West Nigeria) [Elektronische Daten] [L. Jeyakumar, U. Arowoshegbe, O. Akinyinka, F. Akinbami, E. Bababunmi] Summary: Acetylator status was determined in 25 kwashiorkor children, aged between 8 months and 3 years and in 25 age-matched control group of healthy children after a single oral dose of sulphamethazine (40 mg/kg body weight) and by measuring the acetylated sulphamethazine in blood samples, collected 6 h after the administration of sulphamethazine. p ]The percentage of slow acetylators among kwashiorkor children was 40% while among the control group of children it was 48%. The difference between the two groups was not significant. p ]Therefore, it is probable mat the slow acetylator status of the Nigerian African children may not be a contributing factor for the development of kwashiorkor, a syndrome of protein-energy malnutrition. Furthermore, the polymorphic activity of N-acetyl transferase enzyme may not be impaired in kwashiorkor. Springer-Verlag, 1990 Kwashiorkor nationallicence acetylation polymorphism sulphamethazine nationallicence Jeyakumar L. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut Arowoshegbe U. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut Akinyinka O. Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria aut Akinbami F. Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria aut Bababunmi E. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 57-62 0378-7966 15:1<57 1990 15 13318 https://doi.org/10.1007/BF03190128 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190128 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jeyakumar L. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 700 1- Arowoshegbe U. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 700 1- Akinyinka O. Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 700 1- Akinbami F. Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 700 1- Bababunmi E. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 57-62 0378-7966 15:1<57 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer