caa a22 4500 465812155 CHVBK 20180323112119.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03190131 doi (NATIONALLICENCE)springer-10.1007/BF03190131 Comparative kinetics of oxiracetam in serum and CSF of patients with dementia of Alzheimer type [Elektronische Daten] [L. Parnetti, P. Mecocci, A. Gaiti, D. Cadini, F. Lombardi, M. Visconti, U. Senin] Summary: The purpose of the study was to determine whether oxiracetam crosses the human blood-brain barrier and to evaluate its comparative kinetics in serum and in cerebro-spinal fluid (CSF). Six DAT patients, undergoing CSF collection for diagnostic purposes, received 2 g oxiracetam daily, by a 60 min i.v. infusion, for 7 days. On the last day, in four patients blood samples were collected at time 0, 30, 60 and 120 min, and lumbar drainage was performed at the end of infusion: at this time mean CSF concentration was 3.3 μg/ml, i.e. 4.0% of the serum one, demonstrating that oxiracetam crosses the blood-brain barrier. In two patients, blood samples were collected at time 0, 60, 120 and 240 min, and lumbar drainage was performed 60 min after the end of infusion: at this time mean CSF concentration was 2.8 (μg/ml, i.e. 5.3% of the serum one, indicating a persistence of oxiracetam within this deep compartment. These results provide the first evidence in humans that oxiracetam penetrates the central nervous system and contribute to the understanding of its long-lasting pharmacodynamic effect in man. Springer-Verlag, 1990 Oxiracetam nationallicence dementia nationallicence Alzheimer nationallicence pharmacokinetics nationallicence Parnetti L. Policlinico Monteluce, Aging Brain Research Centre, I-06100, Perugia, Italy aut Mecocci P. Policlinico Monteluce, Aging Brain Research Centre, I-06100, Perugia, Italy aut Gaiti A. Perugia University, Italy aut Cadini D. Policlinico Monteluce, Aging Brain Research Centre, I-06100, Perugia, Italy aut Lombardi F. ISF, Laboratories for Biomedical Research, Trezzano s/N, Milano, Italy aut Visconti M. ISF, Laboratories for Biomedical Research, Trezzano s/N, Milano, Italy aut Senin U. Policlinico Monteluce, Aging Brain Research Centre, I-06100, Perugia, Italy aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 75-78 0378-7966 15:1<75 1990 15 13318 https://doi.org/10.1007/BF03190131 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190131 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Parnetti L. Policlinico Monteluce, Aging Brain Research Centre, I-06100, Perugia, Italy aut NATIONALLICENCE 700 1- Mecocci P. Policlinico Monteluce, Aging Brain Research Centre, I-06100, Perugia, Italy aut NATIONALLICENCE 700 1- Gaiti A. Perugia University, Italy aut NATIONALLICENCE 700 1- Cadini D. Policlinico Monteluce, Aging Brain Research Centre, I-06100, Perugia, Italy aut NATIONALLICENCE 700 1- Lombardi F. ISF, Laboratories for Biomedical Research, Trezzano s/N, Milano, Italy aut NATIONALLICENCE 700 1- Visconti M. ISF, Laboratories for Biomedical Research, Trezzano s/N, Milano, Italy aut NATIONALLICENCE 700 1- Senin U. Policlinico Monteluce, Aging Brain Research Centre, I-06100, Perugia, Italy aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 75-78 0378-7966 15:1<75 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer