caa a22 4500 465812163 CHVBK 20180323112119.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03190130 doi (NATIONALLICENCE)springer-10.1007/BF03190130 Kinetic profiles of tianeptine and its MC5 metabolite in plasma, blood and brain after single and chronic intraperitoneal administration in the rat [Elektronische Daten] [W. Couet, J. Girault, F. Latrille, C. Salvadori, J. Fourtillan] Summary: This study was conducted to determine kinetic profiles of the antidepressant tianeptine and its main metabolite (named MC5) in plasma, blood and brain after single (10 mg.kg−1) and chronic (10 mg.kg−1.day−1 and 2 × 10 mg.kg−1day−1 for 15 days) intraperitoneal administration in Wistar rats. In plasma, tianeptine and MC5 reached a peak very quickly (5 and 15 mid post administration respectively). Following the peak, disappearance of tianeptine was faster than that of MC5 with terminal half-lives close to 2.5 and 6.5 h respectively. During chronic treatment, accumulation of tianeptine was negligible, that of MC5 was slight as indicated by accumulation ratios equal to 1.28 (once daily administration) and 1.73 (twice daily administration). Tianeptine and MC5 rapidly appeared in brain tissue but at concentrations less than those observed in plasma. Peak concentrations of tianeptine in brain were higher than those of MC5. A very low penetration of tianeptine and MC5 into erythrocytes was observed. Springer-Verlag, 1990 Tianeptine nationallicence pharmacokinetics nationallicence rat nationallicence Couet W. CEMAF, Poitiers, France aut Girault J. CEMAF, Poitiers, France aut Latrille F. EVIC CEBA, Blanquefort, France aut Salvadori C. IRIS, Courbevoie, France aut Fourtillan J. CEMAF, Poitiers, France aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 69-74 0378-7966 15:1<69 1990 15 13318 https://doi.org/10.1007/BF03190130 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190130 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Couet W. CEMAF, Poitiers, France aut NATIONALLICENCE 700 1- Girault J. CEMAF, Poitiers, France aut NATIONALLICENCE 700 1- Latrille F. EVIC CEBA, Blanquefort, France aut NATIONALLICENCE 700 1- Salvadori C. IRIS, Courbevoie, France aut NATIONALLICENCE 700 1- Fourtillan J. CEMAF, Poitiers, France aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 69-74 0378-7966 15:1<69 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer