caa a22 4500 46581218X CHVBK 20180323112119.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03190120 doi (NATIONALLICENCE)springer-10.1007/BF03190120 Pharmacokinetics of vinpocetine and its main metabolite apovincaminic acid before and after the chronic oral administration of vinpocetine to humans [Elektronische Daten] [P. Miskolczi, K. Kozma, M. Polgár, L. Vereczkey] Summary: The pharmacokinetics of vinpocetine (Cavinton®) and of its main metabolite apovincaminic acid (AVA), has been studied in 5 healthy male volunteers after the administration of 3 × 5 and 3 × 10 daily doses of vinpocetine for seven days. The pharmacokinetic curves of both vinpocetine and AVA have been determined prior to the chronic administration and on the last day of the treatment, whereas between the 2nd and 6th days, concentration was measured once daily. On the basis of these pharmacokinetic studies it can be concluded that both vinpocetine and AVA show linear pharmacokinetics at the doses used and that there is no accumulation or autoinduction. Springer-Verlag, 1990 Pharmacokinetics nationallicence vinpocetine apovincaminic acid nationallicence healthy volunteers nationallicence Miskolczi P. Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, H-1475, P.O. Box 27, 10, Budapest, Hungary aut Kozma K. Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, H-1475, P.O. Box 27, 10, Budapest, Hungary aut Polgár M. Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, H-1475, P.O. Box 27, 10, Budapest, Hungary aut Vereczkey L. Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, H-1475, P.O. Box 27, 10, Budapest, Hungary aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 1-5 0378-7966 15:1<1 1990 15 13318 https://doi.org/10.1007/BF03190120 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190120 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miskolczi P. Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, H-1475, P.O. Box 27, 10, Budapest, Hungary aut NATIONALLICENCE 700 1- Kozma K. Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, H-1475, P.O. Box 27, 10, Budapest, Hungary aut NATIONALLICENCE 700 1- Polgár M. Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, H-1475, P.O. Box 27, 10, Budapest, Hungary aut NATIONALLICENCE 700 1- Vereczkey L. Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, H-1475, P.O. Box 27, 10, Budapest, Hungary aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 1-5 0378-7966 15:1<1 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer