caa a22 4500 46581221X CHVBK 20180323112119.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03190124 doi (NATIONALLICENCE)springer-10.1007/BF03190124 Pharmacokinetics of biliary excretion of N-nitrosodiphenylamine (NDPA) in animals of different species [Elektronische Daten] [S. Atawodi, E. Maduagwu] Summary: Pharmacokinetic investigations into the biliary excretion of N-nitrosodiphenylarnine given as an i.p. dose of 50 mg/kg were conducted and results compared in three animal species; rat, guinea pig and rabbit following bile duct (Simulation and collection of bile in vitro. The guinea pig excreted NDPA into bile fastest while the rabbit, which excreted it slowest, eliminated it fastest Both appearance and disappearance of the nitrosamine were comparatively slow in the rat NDPA elimination half-life values in the animal species were 510, 240 and 95 min respectively, while cumulative excretions amounted to 12, 3 and 0.3 percent. The toxicological implications of these species differences are highlighted. Springer-Verlag, 1990 N-Nitrosodiphenylamine nationallicence bile nationallicence excretion nationallicence pharmacokinetics nationallicence Atawodi S. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut Maduagwu E. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 27-29 0378-7966 15:1<27 1990 15 13318 https://doi.org/10.1007/BF03190124 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190124 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Atawodi S. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 700 1- Maduagwu E. Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 27-29 0378-7966 15:1<27 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer