caa a22 4500 465812228 CHVBK 20180323112119.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03190121 doi (NATIONALLICENCE)springer-10.1007/BF03190121 Pharmacokinetics, hepatic biotransformation and biliary and urinary excretion of bromosulfophthalein (BSP) in an experimental liver disease mimicking biliary cirrhosis [Elektronische Daten] [A. Esteller, M. Torres, M. Gomez-Bauttsta, E. Mariño, C. Fernandez-Lastra, R. Jimenez] Summary: We studied the hepatic handling of bromosulfophthalein in healthy rabbits and in rabbits with hepatic coccidiosis 28 days after an experimental infection with sporulated oocysts of Eimeria stiedai, an experimental model of liver disease histopathologicalry resembling primary biliary cirrhosis in man. A pharmacokinetic study of the results was performed following a multicompartmental model with 7 transfer constants to describe the physiological disposition of the dye. The study showed that the plasma disappearance, distribution volume (Vi), hepatic biotransformation and the biliary and urinary elimination of conjugated (BSPc) and unconjugated (BSPu) bromosulfophthalein were markedly altered. Whereas Vi and urinary excretion of the dye were significantly increased, the hepatic clearance, biotransformation and biliary excretion of BSPc and BSPu were drastically reduced in infected rabbits. Satisfactory agreement was obtained between the experimental and estimated data, particularly those relating to biotransformation clearance and biliary and urinary excretion of the dye. These results demonstrate that severe liver disease in rabbits with histopathological liver alterations resembling several hepatic dysfunctions in man markedly reduce hepatic uptake, metabolism and biliary excretion of a xenobiotic such as BSP. Springer-Verlag, 1990 bromosulfophthalein nationallicence hepatic coccidiosis nationallicence liver disease nationallicence pharmacokinetic model nationallicence Esteller A. Department of Physiology and Pharmacology, University of Salamanca, Spain aut Torres M. Department of Physiology and Pharmacology, University of Salamanca, Spain aut Gomez-Bauttsta M. Department of Physiology and Pharmacology, University of Salamanca, Spain aut Mariño E. Department of Pharmacy, University of Barcelona, Spain aut Fernandez-Lastra C. Department of Pharmacy, University of Barcelona, Spain aut Jimenez R. Department of Physiology and Pharmacology, University of Salamanca, Spain aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 7-14 0378-7966 15:1<7 1990 15 13318 https://doi.org/10.1007/BF03190121 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190121 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Esteller A. Department of Physiology and Pharmacology, University of Salamanca, Spain aut NATIONALLICENCE 700 1- Torres M. Department of Physiology and Pharmacology, University of Salamanca, Spain aut NATIONALLICENCE 700 1- Gomez-Bauttsta M. Department of Physiology and Pharmacology, University of Salamanca, Spain aut NATIONALLICENCE 700 1- Mariño E. Department of Pharmacy, University of Barcelona, Spain aut NATIONALLICENCE 700 1- Fernandez-Lastra C. Department of Pharmacy, University of Barcelona, Spain aut NATIONALLICENCE 700 1- Jimenez R. Department of Physiology and Pharmacology, University of Salamanca, Spain aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 7-14 0378-7966 15:1<7 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer