caa a22 4500 465812236 CHVBK 20180323112119.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03190122 doi (NATIONALLICENCE)springer-10.1007/BF03190122 Effect of enzyme induction on bioavailability of hetacillin in patients treated with anticonvulsants and chlorpromazine [Elektronische Daten] [P. Galanopoulou, Ch. Karageorgiou, K. Dimakopoulou] Summary: The effect of liver enzyme induction on bioavailability of hetacillin was studied in patients chronically treated with anticonvulsants or chlorpromazine. 24 chronic psychiatric patients classified according to their medication in two groups (anticonvulsants, chlorpromazine) and one group of 11 healthy volunteers, received an i.m. administration of 500 mg hetacillin. Serum levels of arnpicillin derived from hetacillin in blood samples taken 2, 4 and 6 hours after the injection were measured and the half-life of the antibiotic was determined for each group. Urinary D-glucaric acid was considered the induction index. Correlation coefficients between the induction index and pharmacokinetic parameters of hetacillin were also determined. Anticonvulsants and chlorpromazine induced the liver microsomal enzymes as demonstrated by the increased D-glucaric acid excretion (P<0.001 —P<0.05). No statistically significant differences were found in serum levels and half-life of the antibiotic. Correlation coefficients suggest that enzyme induction and hetacillin bioavailability are not significantly related. Springer-Verlag, 1990 Enzyme induction nationallicence D-glucaric acid nationallicence psychiatric patients nationallicence anticonvulsants nationallicence chlorpromazine nationallicence hetacillin nationallicence arnpicillin nationallicence pharmacokinetics nationallicence bioavailability nationallicence Galanopoulou P. Department of Experimental Pharmacology, Medical School, Athens University, 115 27, Athens, Greece aut Karageorgiou Ch Department of Experimental Pharmacology, Medical School, Athens University, 115 27, Athens, Greece aut Dimakopoulou K. State Mental Hospital of Athens, Greece aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 15-18 0378-7966 15:1<15 1990 15 13318 https://doi.org/10.1007/BF03190122 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190122 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Galanopoulou P. Department of Experimental Pharmacology, Medical School, Athens University, 115 27, Athens, Greece aut NATIONALLICENCE 700 1- Karageorgiou Ch Department of Experimental Pharmacology, Medical School, Athens University, 115 27, Athens, Greece aut NATIONALLICENCE 700 1- Dimakopoulou K. State Mental Hospital of Athens, Greece aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 15-18 0378-7966 15:1<15 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer