caa a22 4500 465812244 CHVBK 20180323112119.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03190125 doi (NATIONALLICENCE)springer-10.1007/BF03190125 Tissue distribution and elimination of14C-aminoglutethimide in the mouse [Elektronische Daten] [P. Dalrymple, P. Nicholls] Summary: Following oral administration of14C-amkoglutethimide (Orimeten), male mice excreted 75% and female mice 59% of the administered dose during 24 h. After 72 h, elimination was essentially complete in male mice, whilst recovery from female mice was 74%. As assessed by quantitative assay and whole-body autoradiography, a wide distribution of radioactivity was found with high concentrations of radioactivity occurring only in the bile, gastro-intestinal tract and liver at early times. Residual (72 h) tissue levels of radioactivity were < 1 μg equiv. of14C-ammoglutethimide/g tissue. Metabolite profiles in urine, tissues and faeces showed extensive metabolism of the drug in a pattern similar to that found in the rat. Springer-Verlag, 1990 14C-animoglutethimide nationallicence distribution nationallicence mouse nationallicence Dalrymple P. Welsh School of Pharmacy, U.W.C.C., Cardiff, UK aut Nicholls P. Welsh School of Pharmacy, U.W.C.C., Cardiff, UK aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 31-35 0378-7966 15:1<31 1990 15 13318 https://doi.org/10.1007/BF03190125 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190125 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dalrymple P. Welsh School of Pharmacy, U.W.C.C., Cardiff, UK aut NATIONALLICENCE 700 1- Nicholls P. Welsh School of Pharmacy, U.W.C.C., Cardiff, UK aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/1(1990-01-01), 31-35 0378-7966 15:1<31 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer