caa a22 4500 465812260 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03190211 doi (NATIONALLICENCE)springer-10.1007/BF03190211 Mephenytoin stereoselective elimination in the rat: III. Stereoselective time course of induction during chronic hepatic portal vein administration [Elektronische Daten] [S. Akrawi, P. Wedlund] Summary: The blood concentrations of R- and S-mephenytoin were followed in seven rats over a 5-8 day period during a hepatic portal vein infusion of racemic mephenytoin. In all but two rats, both of the enantiomers achieved an initial steady-state level before a measurable change was observed in their blood concentrations. In each case, the decrease in the initial S-mephenytoin steady state blood level occurred after the change in R-mephenytoin was apparent. During the period of study, the mean±SD portal vein clearance of S-mephenytoin increased from 96±33 ml/h to 450±160 ml/h. The mean±SD portal vein clearance of R-mephenytoin increased from 170±50 ml/h to 2400±1600 ml/h. The larger increase in the portal vein clearance for the R-enantiomer resulted in the R/S-mephenytoin clearance ratio over this same time period changing from 1.8±0.2 to 5.2±1.8. Attempts to describe the time course of change in the clearance of S- or R-mephenytoin using a previously reported model of induction were unsuccessful. The induction time course did suggest, however, that the rate of induction may be similar for each enantiomer. Springer-Verlag, 1990 Mephenytoin nationallicence enantiomers nationallicence stereoselective nationallicence induction time nationallicence drug clearance nationallicence Akrawi S. College of Pharmacy, University of Baghdad, Baghdad, Iraq aut Wedlund P. College of Pharmacy, University of Kentucky, 40536-0082, Lexington, KY, USA aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 245-251 0378-7966 15:3<245 1990 15 13318 https://doi.org/10.1007/BF03190211 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190211 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akrawi S. College of Pharmacy, University of Baghdad, Baghdad, Iraq aut NATIONALLICENCE 700 1- Wedlund P. College of Pharmacy, University of Kentucky, 40536-0082, Lexington, KY, USA aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 245-251 0378-7966 15:3<245 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 46519415X BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer