caa a22 4500 465812295 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03190206 doi (NATIONALLICENCE)springer-10.1007/BF03190206 Quantitative structure — pharmacokinetic relationship of a series of sulfonamides in the rat [Elektronische Daten] [S. Kaul, W. Ritschel] Summary: The pharmacokinetics of a series of sulfonamides were investigated after intravenous administration of a 7 mg/kg dose of individual sulfonamides to cannulated female lean Zucker rats. The concentrations of the sulfonamides in blood were determined by colorimetry. The blood concentration-time curves were fitted to a biexponential equation. The partition coefficient, log P, and pKa values of the sulfonamides were taken from the literature, log P and pKa values differed markedly across the series. The extent of protein binding varied enormously, increasing with partition coefficient. There was no significant relationship between the volume of distribution and partition coefficient. However, when the influence of protein binding on volume of distribution was eliminated, a significant linear relationship emerged. Total clearance formed a relatively complex nonlinear relationship with partition coefficient. The relationship of elimination half-life and partition coefficient was inverwe of that between clearance and partition coefficient because of a lack of significant relationship between volume of distribution and partition coefficient. Springer-Verlag, 1990 Sulfonamides nationallicence structure-pharmacokinetic relationships nationallicence rats nationallicence Kaul S. Division of Pharmaceutics and Drug Delivery Systems, University of Cincinnati Medical Center, College of Pharmacy, Cincinnati, Ohio, USA aut Ritschel W. Division of Pharmaceutics and Drug Delivery Systems, University of Cincinnati Medical Center, College of Pharmacy, Cincinnati, Ohio, USA aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 211-217 0378-7966 15:3<211 1990 15 13318 https://doi.org/10.1007/BF03190206 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190206 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaul S. Division of Pharmaceutics and Drug Delivery Systems, University of Cincinnati Medical Center, College of Pharmacy, Cincinnati, Ohio, USA aut NATIONALLICENCE 700 1- Ritschel W. Division of Pharmaceutics and Drug Delivery Systems, University of Cincinnati Medical Center, College of Pharmacy, Cincinnati, Ohio, USA aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 211-217 0378-7966 15:3<211 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer