caa a22 4500 465812317 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03190204 doi (NATIONALLICENCE)springer-10.1007/BF03190204 Effect of experimentally-induced hepatic cirrhosis on the pharmacokinetics of orally administered praziquantel in the rat [Elektronische Daten] [G. Kokwaro, G. Taylor] Summary: The effects of pretreatment with the hepatotoxin, thioacetamide, on the pharmacokinetics of praziquantel, a broad spectrum schistosomicidal agent with a high hepatic clearance, were studied in male Wistar rats. Animals were pretreated with either thioacetamide (25 mg in 100 ml of drinking water, n=5) for 24 weeks or received plain drinking water (n=5) over the same period. After the treatment period, praziquantel was administered orally (25 mg/kg as a 20 mg/ml solution in PEG 200) as a single dose. Blood samples (0.3 ml) were collected from the clipped tail at various times up to 4 h post administration. Plasma was analysed for praziquantel using an HPLC method. Mean peak plasma praziquantel concentrations were approximately 1.0 mg/l for both groups. The time to reach peak concentrations, and post-peak elimination half-life, were approximately 0.7 h and 1.0 h, respectively, for both groups. Similarly, mean AUC was approximately 2.0 mg.h/l for both groups. Statistical comparisons indicated that there were no significant differences in the pharmacokinetic parameters estimated in the two groups of animals. It was concluded that thioacetamide-induced hepatic cirrhosis has no effect on the pharmacokinetics of orally administered praziquantel in the rat, at the dose level studied. Springer-Verlag, 1990 Praziquantel nationallicence pharmacokinetics nationallicence thioacetamide nationallicence cirrhosis nationallicence Kokwaro G. Welsh School of Pharmacy, University of Wales, P.O. Box 13, Cardiff CF1 3XF, Wales, UK aut Taylor G. Welsh School of Pharmacy, University of Wales, P.O. Box 13, Cardiff CF1 3XF, Wales, UK aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 199-202 0378-7966 15:3<199 1990 15 13318 https://doi.org/10.1007/BF03190204 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190204 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kokwaro G. Welsh School of Pharmacy, University of Wales, P.O. Box 13, Cardiff CF1 3XF, Wales, UK aut NATIONALLICENCE 700 1- Taylor G. Welsh School of Pharmacy, University of Wales, P.O. Box 13, Cardiff CF1 3XF, Wales, UK aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 199-202 0378-7966 15:3<199 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer