caa a22 4500 465812333 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03190212 doi (NATIONALLICENCE)springer-10.1007/BF03190212 In vitro metabolism of cannabinol in rat, mouse, rabbit, guinea pig, hamster, gerbil and cat [Elektronische Daten] [N. Brown, D. Harvey] Summary: Metabolism of cannabinol (CBN) was studied in hepatic microsomal incubates from mouse, rat, rabbit, guinea pig, cat, hamster and gerbil. Metabolites were extracted with ethyl acetate, concentrated by chromatography on Sephadex LH-20 and identified by GC/MS as TMS derivatives. Six monohydroxy metabolites were identified. These had hydroxy groups at C-11, and at all positions of the pentyl side-chain. Metabolism varied considerably between the species. 11-Hydroxylation was the most prominent route in the majority of species, but in the hamster and cat the major metabolic pathway was 4′-hydroxylation. Metabolites hydroxylated in the pentyl chain were generally more abundant in guinea pig, hamster and cat. Springer-Verlag, 1990 Cannabinol nationallicence cat nationallicence gerbil nationallicence guinea pig nationallicence hamster nationallicence liver nationallicence mass spectrometry nationallicence mouse nationallicence rabbit nationallicence rat nationallicence Brown N. Department of Pharmacology, University of Oxford, South Parks Road, OX1 3QT, Oxford, UK aut Harvey D. Department of Pharmacology, University of Oxford, South Parks Road, OX1 3QT, Oxford, UK aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 253-258 0378-7966 15:3<253 1990 15 13318 https://doi.org/10.1007/BF03190212 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190212 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brown N. Department of Pharmacology, University of Oxford, South Parks Road, OX1 3QT, Oxford, UK aut NATIONALLICENCE 700 1- Harvey D. Department of Pharmacology, University of Oxford, South Parks Road, OX1 3QT, Oxford, UK aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 253-258 0378-7966 15:3<253 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer