caa a22 4500 465812341 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03190202 doi (NATIONALLICENCE)springer-10.1007/BF03190202 Evaluation of first pass effect and biliary excretion of diperdipine in the dog [Elektronische Daten] [P. Greiner, S. Weber, J. Angignard, B. Berbey] Summary: Intravenous, oral and intraportal doses of diperdipine were given to bile duct cannulated dogs in order to assess the impact of first pass effect on the pharmacokinetics of this compound. After intravenous and oral doses, absolute bioavailability was calculated to be 18.7%. Biliary excretion accounted for about 0.1% of the total clearance of diperdipine and did not contribute to the overall elimination of the drug. After intraportal administration, the bioavailable fraction of diperdipine was increasing up to 44.3% suggesting a prehepatic site of loss of the drug. This was also substantiated by the fact that after oral administration a lesser fraction was excreted in the bile, than after the intraportal dose. The drug was highly bound to plasma proteins (>96%) and was largely distributed in the blood cells for which a concentration dependent process was observed. Springer-Verlag, 1990 diperdipine nationallicence pharmacokinetics nationallicence first pass effect nationallicence dog nationallicence biliary excretion nationallicence Greiner P. Department of Pharmacokinetics, SIR International, 6 rue Blanche, p-92120, Montrouge, France aut Weber S. Department of Physiology, SIR International, Montrouge, France aut Angignard J. Department of Physiology, SIR International, Montrouge, France aut Berbey B. Department of Physiology, SIR International, Montrouge, France aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 185-190 0378-7966 15:3<185 1990 15 13318 https://doi.org/10.1007/BF03190202 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190202 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Greiner P. Department of Pharmacokinetics, SIR International, 6 rue Blanche, p-92120, Montrouge, France aut NATIONALLICENCE 700 1- Weber S. Department of Physiology, SIR International, Montrouge, France aut NATIONALLICENCE 700 1- Angignard J. Department of Physiology, SIR International, Montrouge, France aut NATIONALLICENCE 700 1- Berbey B. Department of Physiology, SIR International, Montrouge, France aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/3(1990-07-01), 185-190 0378-7966 15:3<185 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer