caa a22 4500 465812376 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03190218 doi (NATIONALLICENCE)springer-10.1007/BF03190218 Glucuronidation of 7-hydroxy-4-methylcoumarin by human liver microsomes. Inhibition by certain drugs [Elektronische Daten] [Y. Irshaid, K. Gharaybeh, F. Ammari, N. Rawashdeh] Summary: Glucuronidation of 7-hydroxy-4-methylcoumarin (7-OH-4-MC) was comparable in three of the four human liver samples studied. In liver sample IV the glucuronidation rate of 7-OH-4-MC was almost 40% of that in the other samples. That might be due to interindividual variation in the capacity to glucuronidate. Glucuronidation rates were not reduced in the one human liver sample which displayed mild centrilobular cholestasis on histopathology. Furosemide (FR), salicylic acid (SA), lorazepam (Z) and menthol (MT) inhibited the glucuronidation of 7-OH-4-MC to varying degrees (30-90%). Paracetamol (PA) and 5-hydroxytryptamine (HT) were not inhibitors of the glucuronidation of 7-OH-4-MC. These findings suggest the presence of other UDP-glucuronosyltransferase (UDPGT) isozymes in the human liver microsomes which are responsible for the glucuronidation of PA and HT than those which glucuronidate 7-OH-4-MC. Springer-Verlag, 1990 Glucuronidation nationallicence human liver microsomes nationallicence inhibition nationallicence 7-hydroxy-4-methylcoumarin nationallicence Irshaid Y. Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan aut Gharaybeh K. Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan aut Ammari F. Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan aut Rawashdeh N. Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 295-301 0378-7966 15:4<295 1990 15 13318 https://doi.org/10.1007/BF03190218 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190218 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Irshaid Y. Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan aut NATIONALLICENCE 700 1- Gharaybeh K. Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan aut NATIONALLICENCE 700 1- Ammari F. Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan aut NATIONALLICENCE 700 1- Rawashdeh N. Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 295-301 0378-7966 15:4<295 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer