caa a22 4500 465812384 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03190217 doi (NATIONALLICENCE)springer-10.1007/BF03190217 Bechtel W. Department of Biochemistry, Boehringer Ingelheim KG, D-6507, Ingelheim am Rhein, FRG aut Blood level, metabolism and excretion of [14C]-brotizolam in mice [Elektronische Daten] [W. Bechtel] Summary: Blood level, metabolite pattern and excretion of [14C]-brotizolam, a hypnotic drug, were studied in mice following oral administraiton. [14C]-Brotizolam was rapidly absorbed which was indicated by a Tmax of the blood level of 0.5 h. Radioactive compounds were eliminated from the blood with a half-life of 5.6 h. Total excretion of radioactivity, the renal portion of which was 22.4%, was complete after 4 days. [14C]-Brotizolam was almost completely metabolized. Using TLC, HPLC and radioactivity measurement, the main metabolite in bile, urine and plasma was found to be brotizolam hydroxylated at the methyl group. Other major metabolites were brotizolam hydroxylated at the diazepine ring and a combination of both hydroxylations. In the bile, all metabolites were conjugated. The metabolism of brotizolam in mice is similar to that in dogs, monkeys and man but not in rats. Springer-Verlag, 1990 Brotizolam nationallicence blood level nationallicence pharmacokinetics nationallicence metabolism nationallicence excretion nationallicence mice nationallicence European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 287-293 0378-7966 15:4<287 1990 15 13318 https://doi.org/10.1007/BF03190217 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190217 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bechtel W. Department of Biochemistry, Boehringer Ingelheim KG, D-6507, Ingelheim am Rhein, FRG aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 287-293 0378-7966 15:4<287 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer