caa a22 4500 465812422 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03190216 doi (NATIONALLICENCE)springer-10.1007/BF03190216 Diabetes in female rats; changes in liver microsomal aminopyrine N-demethylase and UDP-glucuronyl transferase activities [Elektronische Daten] [Eugenia Del Villar, Patricio Vega, Carlos Gaule, Emilio Sanchez] Summary: Short or long term diabetes in female rats produced remarkable activation of aminopyrine N-demethylation, inhibition of oestrone and p-nitrophenol glucuronidation and no changes in morphine UDP-glucuronyltransferase activityin vitro. Km and Vmax for these reactions were determined. Insulin treatment partially antagonized diabetes activation of aminopyrine N-demethylation: it restored decreased UDPglucuronyltransferase activities for oestrone and p-nitrophenol only in long term and short term diabetes, respectively. Insulin also markedly inhibited morphine glucuronidation. Triton X-100 also displayed a differential pattern of activation for the glucuronidation reactions in liver microsomes of diabetic rats. Results suggest that diabetes in female rats may increase the actual amount of enzyme protein for aminopyrine metabolism and to decrease that for oestrone and p-nitrophenol. Springer-Verlag, 1990 UDP-glucuronyltransferase nationallicence alloxan diabetes nationallicence cytochrome p-450 nationallicence Del Villar Eugenia Department of Biochemistry, Faculty of Medicine, University of Chile, P.O. Box 70086, Santiago 7, Chile aut Vega Patricio Department of Biochemistry, Faculty of Medicine, University of Chile, P.O. Box 70086, Santiago 7, Chile aut Gaule Carlos Department of Biochemistry, Faculty of Medicine, University of Chile, P.O. Box 70086, Santiago 7, Chile aut Sanchez Emilio Department of Biochemistry, Faculty of Medicine, University of Chile, P.O. Box 70086, Santiago 7, Chile aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 279-285 0378-7966 15:4<279 1990 15 13318 https://doi.org/10.1007/BF03190216 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190216 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Del Villar Eugenia Department of Biochemistry, Faculty of Medicine, University of Chile, P.O. Box 70086, Santiago 7, Chile aut NATIONALLICENCE 700 1- Vega Patricio Department of Biochemistry, Faculty of Medicine, University of Chile, P.O. Box 70086, Santiago 7, Chile aut NATIONALLICENCE 700 1- Gaule Carlos Department of Biochemistry, Faculty of Medicine, University of Chile, P.O. Box 70086, Santiago 7, Chile aut NATIONALLICENCE 700 1- Sanchez Emilio Department of Biochemistry, Faculty of Medicine, University of Chile, P.O. Box 70086, Santiago 7, Chile aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 279-285 0378-7966 15:4<279 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer