caa a22 4500 465812430 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03190215 doi (NATIONALLICENCE)springer-10.1007/BF03190215 Pharmacokinetics of nifedipine derived from a new retard tablet formulation [Elektronische Daten] [A. Avgerinos, J. Gorrod] Summary: A nifedipine retard tablet formulation (Glopir, 20mg) was developed to reduce the number of daily doses required in the treatment of hypertension. The plasma pharmacokinetics of this oral formulation were examined, in a single study, on 12 healthy volunteers. Single 20 mg doses of nifedipine retard tablet (Glopir, GAP & Co. Athens, Greece) were given after an overnight fast and 10 blood samples were drawn during the first 24 h after administration. Plasma concentrations of nifedipine were measured by high performance liquid chromatography. The mean peak plasma nifedipine concentration was 27.6 ng/ml at a maximum time of 24 h, after tablet ingestion. The mean apparent nifedipine elimination half-life was 16.0±7.5 h and the mean area under the plasma concentration time curve (0-24 h) 404.1±134.0 ng/ml.h. The data suggest that the tablet form has properties of a sustained-release preparation, with slow accumulation and elimination phases and can appropriately be given in a twice-daily regimen. Springer-Verlag, 1990 Nifedipine nationallicence retard tablet nationallicence pharmacokinetics nationallicence Avgerinos A. Military Pharmaceutical Laboratories, 174 Pireos Street, 177 78, Athens, Greece aut Gorrod J. Chelsea Department of Pharmacy, King's College, University of London, London, UK aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 273-278 0378-7966 15:4<273 1990 15 13318 https://doi.org/10.1007/BF03190215 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190215 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Avgerinos A. Military Pharmaceutical Laboratories, 174 Pireos Street, 177 78, Athens, Greece aut NATIONALLICENCE 700 1- Gorrod J. Chelsea Department of Pharmacy, King's College, University of London, London, UK aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 273-278 0378-7966 15:4<273 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer