caa a22 4500 465812457 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03190224 doi (NATIONALLICENCE)springer-10.1007/BF03190224 Metabolism of amineptine in rat, dog and man [Elektronische Daten] [L. Grislain, P. Gelé, N. Bromet, W. Luijten, J. Volland, E. Mocaer, A. Kamoun] Summary: After oral administration of amineptine (7-[(10-ll)-dihydro-5H-dibenzo(a,d)cycloheptane-5yl] amino heptanoic acid), an original tricyclic antidepressant, seven metabolites were isolated from urine and plasma of rat, dog and man. The metabolic pathways were similar for the three species studied. The two major pathways consisted of the β-oxidation of the heptanoic side chain leading to pentanoic (first step) and propanoic (second step) side chain metabolites and the hydroxylation of the dibenzocycloheptyl ring on carbon atom 10 (C10) causing the formation of two diastereoisomers. Lactamization by internal dehydration of β-oxidized metabolites appeared to be a minor route of biotransformation. Conjugation reactions were of minor importance in the rat, in contrast to findings for dog and man. Urinary elimination was the major route of excretion in man while in dog and in rat faecal excretion was predominant. Springer-Verlag, 1990 Amineptine nationallicence metabolism nationallicence rat nationallicence dog nationallicence man nationallicence Grislain L. Bio-Pharmacie Servier, 5 rue de Bel Air, F-45000, Orléans, France aut Gelé P. Bio-Pharmacie Servier, 5 rue de Bel Air, F-45000, Orléans, France aut Bromet N. Bio-Pharmacie Servier, 5 rue de Bel Air, F-45000, Orléans, France aut Luijten W. Bio-Pharmacie Servier, 5 rue de Bel Air, F-45000, Orléans, France aut Volland J. Institut de Recherches Servier, Suresnes, France aut Mocaer E. Institut de Recherches Internationales Servier, Neuilly sur Seine, France aut Kamoun A. Institut de Recherches Internationales Servier, Neuilly sur Seine, France aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 339-345 0378-7966 15:4<339 1990 15 13318 https://doi.org/10.1007/BF03190224 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190224 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grislain L. Bio-Pharmacie Servier, 5 rue de Bel Air, F-45000, Orléans, France aut NATIONALLICENCE 700 1- Gelé P. Bio-Pharmacie Servier, 5 rue de Bel Air, F-45000, Orléans, France aut NATIONALLICENCE 700 1- Bromet N. Bio-Pharmacie Servier, 5 rue de Bel Air, F-45000, Orléans, France aut NATIONALLICENCE 700 1- Luijten W. Bio-Pharmacie Servier, 5 rue de Bel Air, F-45000, Orléans, France aut NATIONALLICENCE 700 1- Volland J. Institut de Recherches Servier, Suresnes, France aut NATIONALLICENCE 700 1- Mocaer E. Institut de Recherches Internationales Servier, Neuilly sur Seine, France aut NATIONALLICENCE 700 1- Kamoun A. Institut de Recherches Internationales Servier, Neuilly sur Seine, France aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 339-345 0378-7966 15:4<339 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer