caa a22 4500 465812473 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03190214 doi (NATIONALLICENCE)springer-10.1007/BF03190214 Nutritional factors of microsomal enzymatic induction: influence of lipidic components of the diet [Elektronische Daten] [J. Mounie, H. Goudonnet, C. Prevost, L. Champion, R. Truchot, A. Escousse] Summary: We compared the ability of two different diets containing 6 per cent of maize oil and 6 per cent offish oil to modify: firstly the enzyme induction by phenobarbital and secondly the phenobarbital hydroxylation by the liver either in vivo or during in vitro perfusions. The presence of fish oil in the diet increased the cyt P 450 content and the bilirubin glucuronosyl transferase activity. The two induction effects promoted by the association of the phenobarbital treatment and the eating of the fish oil were not additive and it was found that the phenobarbital induction effect was decreased by the fish oil consumption. Phenobarbital and p-hydroxyphenobarbital kinetics were different in the two groups of animals. Phenobarbital was more slowly eluted in the fish oil fed than in the maize oil fed rats while p-hydroxyphenobarbital was more slowly eluted by the fish oil-fed rat livers. Springer-Verlag, 1990 Phenobarbital pharmacokinetics nationallicence phenobarbital metabolism nationallicence microsomial enzymatic activities nationallicence perfused rat liver nationallicence cytochrome P 450 nationallicence UDP-glucuronosyltransferases nationallicence Mounie J. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut Goudonnet H. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut Prevost C. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut Champion L. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut Truchot R. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut Escousse A. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 265-271 0378-7966 15:4<265 1990 15 13318 https://doi.org/10.1007/BF03190214 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190214 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mounie J. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut NATIONALLICENCE 700 1- Goudonnet H. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut NATIONALLICENCE 700 1- Prevost C. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut NATIONALLICENCE 700 1- Champion L. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut NATIONALLICENCE 700 1- Truchot R. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut NATIONALLICENCE 700 1- Escousse A. Formation de Biochimie pharmacoiogique, 7, Bd Jeanne d 'Arc, 21033, Dijon Cedex, France aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/4(1990-10-01), 265-271 0378-7966 15:4<265 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer