caa a22 4500 465812503 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03190199 doi (NATIONALLICENCE)springer-10.1007/BF03190199 Wilson G. Department of Drug Delivery, SmithKline Beecham Pharmaceuticals, P.O. Box 1539, 19406-0939, King of Prussia, PA, USA aut Cell culture techniques for the study of drug transport [Elektronische Daten] [G. Wilson] Summary: The growth of differentiated cell monolayers on microporous filters is providing powerful new techniques for investigating the transport of drug and delivery systems across defined cellular barriers, and for discriminating between different routes and mechanisms. The growth, characterization and potential use of these systems is illustrated by studies on the human Caco-2 cell system which provides an in vitro model of the intestinal epithelial barrier. This system, still in the early stages of characterization and development, displays a number of carrier-mediated and vesicular transport systems found in the intestine in vivo, and is thus providing a useful system for studying the intestinal transport of drugs including peptides and proteins. Springer-Verlag, 1990 Cell culture nationallicence drug transport nationallicence drug delivery nationallicence drug absorption nationallicence biological barriers nationallicence European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/2(1990-04-01), 159-163 0378-7966 15:2<159 1990 15 13318 https://doi.org/10.1007/BF03190199 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190199 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Wilson G. Department of Drug Delivery, SmithKline Beecham Pharmaceuticals, P.O. Box 1539, 19406-0939, King of Prussia, PA, USA aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/2(1990-04-01), 159-163 0378-7966 15:2<159 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer