caa a22 4500 46581252X CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03190196 doi (NATIONALLICENCE)springer-10.1007/BF03190196 Non-invasive methods to study drug disposition: Positron Emission Tomography Detection and quantification of brain receptors in man [Elektronische Daten] [B. Sadzot, G. Franck] Summary: Positron emission tomography (PET) has been used mostly for the study of brain blood flow and metabolism in normal controls and in a variety of neurological and psychiatric conditions. With the appropriate radiotracers, PET also allows non-invasive imaging and quantification of a growing list of neuroreceptors, the target of most psychotropic drugs. For example,11C-carfentanil and11C-diprenorphine, two potent opiate ligands, have been used to label opiate receptors in vivo in man. Methods have been developed to quantify receptor studies with PET in terms of receptor density and affinity. PET is a unique tool that now allows measurement of receptor occupancy in vivo and could be used by the pharmacologist to optimize drug treatment. Springer-Verlag, 1990 Positron Emission Tomography nationallicence neuroreceptors nationallicence opiates nationallicence receptor occupancy nationallicence Sadzot B. The Cyclotron Research Center, University of Liége, Bat. B30, B-4000, Liége-Sart Tilman, Belgium aut Franck G. The Cyclotron Research Center, University of Liége, Bat. B30, B-4000, Liége-Sart Tilman, Belgium aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/2(1990-04-01), 135-142 0378-7966 15:2<135 1990 15 13318 https://doi.org/10.1007/BF03190196 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190196 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sadzot B. The Cyclotron Research Center, University of Liége, Bat. B30, B-4000, Liége-Sart Tilman, Belgium aut NATIONALLICENCE 700 1- Franck G. The Cyclotron Research Center, University of Liége, Bat. B30, B-4000, Liége-Sart Tilman, Belgium aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/2(1990-04-01), 135-142 0378-7966 15:2<135 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer