caa a22 4500 465812538 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03190193 doi (NATIONALLICENCE)springer-10.1007/BF03190193 Demonstration of stereoselective disposition of warfarin enantiomers by whole-body autoradiography [Elektronische Daten] [I. Szinai, M. Simonyi, I. Fitos, Zs. Tegyey, A. Magyar] Summary: The oral anticoagulant warfarin and its14C-labelled derivative are commercially available in racemic forms. Two methods for the chromatographic resolution of the radiolabel were used to investigate the distribution of radioactivity of individual enantiomers in the rat by whole-body autoradiography. Computer-assisted quantification of autoradiograms indicated the average disappearance oflevo-warfarin and its metabolites to be substantially slower than that ofdextro-warfarin and its metabolites from the following organs: liver, pancreas, kidney, lung, blood, intestines. Springer-Verlag, 1990 Resolution of [14C] rac -warfarin nationallicence stereoselective whole-body autoradiography nationallicence computer-assisted quantification of autoradiograms nationallicence Szinai I. Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut Simonyi M. Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut Fitos I. Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut Tegyey Zs Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut Magyar A. Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/2(1990-04-01), 103-107 0378-7966 15:2<103 1990 15 13318 https://doi.org/10.1007/BF03190193 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190193 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Szinai I. Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut NATIONALLICENCE 700 1- Simonyi M. Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut NATIONALLICENCE 700 1- Fitos I. Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut NATIONALLICENCE 700 1- Tegyey Zs Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut NATIONALLICENCE 700 1- Magyar A. Central Research Institute for Chemistry, Hungarian Academy of Sciences, Pf 17, H-1525, Budapest, Hungary aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/2(1990-04-01), 103-107 0378-7966 15:2<103 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer