caa a22 4500 465812597 CHVBK 20180323112120.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03190191 doi (NATIONALLICENCE)springer-10.1007/BF03190191 Transport of peptide and protein drugs across biological membranes [Elektronische Daten] [J. Verhoef, H. Boddé, A. de Boer, J. Bouwstra, H. Junginger, F. Merkus, D. Breimer] Summary: The transport characteristics of peptide and proteins drugs across various epithelial membrane barriers are outlines. These include transport through the intestinal, buccal, nasal and pulmonary absorptive mucosae, as well as transdermal penetration. Because peptides and proteins are hydrophilic and high molecular weight compounds, they commonly show minor permeability across the mentioned biological membranes. In order to improve their transport properties and thereby their systemic bioavailability, several strategies can be undertaken, such as the synthesis of stabilized and lipophilic analoques, the application of absortion enhancers and protease inhibitors, and the design of suitable dosage forms (e.g., liposomes, biodegradable nanocapsules, bioadhesive microspheres). Springer-Verlag, 1990 Peptides nationallicence protein drugs nationallicence biological membranes nationallicence Verhoef J. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut Boddé H. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut de Boer A. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut Bouwstra J. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut Junginger H. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut Merkus F. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut Breimer D. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/2(1990-04-01), 83-93 0378-7966 15:2<83 1990 15 13318 https://doi.org/10.1007/BF03190191 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03190191 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Verhoef J. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut NATIONALLICENCE 700 1- Boddé H. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut NATIONALLICENCE 700 1- de Boer A. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut NATIONALLICENCE 700 1- Bouwstra J. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut NATIONALLICENCE 700 1- Junginger H. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut NATIONALLICENCE 700 1- Merkus F. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut NATIONALLICENCE 700 1- Breimer D. Center for Bio-Pharmaceutical Sciences, Leiden Univercity, P.O. Box 9502, 2300 RA, Leiden, The Nederlands aut NATIONALLICENCE 773 0- European Journal of Drug Metabolism and Pharmacokinetics Springer-Verlag 15/2(1990-04-01), 83-93 0378-7966 15:2<83 1990 15 13318 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer