caa a22 4500 465820360 CHVBK 20180323112134.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01233100 doi (NATIONALLICENCE)springer-10.1007/BF01233100 Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2 [Elektronische Daten] [Nicholas Popescu, Sheue-yann Cheng] A cDNA for the gene that encodes a human cytosolic thyroid hormone binding protein (p58) recently has been isolated and sequenced. Analysis of the p58 sequence indicates that it is identical to the subunit of pyruvate kinase, subtype M2. By in situ hybridization, the gene for p58 was mapped to 15q24-25. This localization shows that the p58 gene is not linked to the L-type of pyruvate kinase, which is located on chromosome 1. The p58 gene was found to be activated in several forms of cancer. Current localization will permit us to assess the effect of alterations involving chromosome 15 on the structure and activity of the p58 gene in neoplasms or chromosome syndromes. Plenum Publishing Corporation, 1990 Popescu Nicholas Laboratorie of Biology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland aut Cheng Sheue-yann Laboratorie of Molecular Biology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland aut Somatic Cell and Molecular Genetics Kluwer Academic Publishers-Plenum Publishers 16/6(1990-11-01), 593-598 0740-7750 16:6<593 1990 16 11188 https://doi.org/10.1007/BF01233100 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01233100 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Popescu Nicholas Laboratorie of Biology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland aut NATIONALLICENCE 700 1- Cheng Sheue-yann Laboratorie of Molecular Biology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland aut NATIONALLICENCE 773 0- Somatic Cell and Molecular Genetics Kluwer Academic Publishers-Plenum Publishers 16/6(1990-11-01), 593-598 0740-7750 16:6<593 1990 16 11188 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer